Academic Journal
A Dual Zinc plus Arginine formulation attenuates the pathogenic properties of Porphyromonas gingivalis and protects gingival keratinocyte barrier function in an in vitro model
| العنوان: | A Dual Zinc plus Arginine formulation attenuates the pathogenic properties of Porphyromonas gingivalis and protects gingival keratinocyte barrier function in an in vitro model |
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| المؤلفون: | Amel Ben Lagha, Ying Yang, Harsh M. Trivedi, James G. Masters, Daniel Grenier |
| المصدر: | Journal of Oral Microbiology, Vol 12, Iss 1 (2020) |
| بيانات النشر: | Taylor & Francis Group, 2020. |
| سنة النشر: | 2020 |
| المجموعة: | LCC:Infectious and parasitic diseases LCC:Microbiology |
| مصطلحات موضوعية: | arginine, dentifrice, epithelial barrier, gingipain, periodontal disease, periodontitis, porphyromonas gingivalis, toothpaste, zinc, Infectious and parasitic diseases, RC109-216, Microbiology, QR1-502 |
| الوصف: | Background and objectives Porphyromonas gingivalis, a late colonizer of the periodontal biofilm, has been strongly associated with the chronic form of periodontitis. The aim of this study was to investigate the effects of a Dual Zinc plus Arginine formulation (aqueous solution and dentifrice) on the pathogenic properties of P. gingivalis and the barrier function of an in vitro gingival epithelium model. Results The Dual Zinc plus Arginine aqueous solution and dentifrice inhibited the hemolytic and proteolytic activities of P. gingivalis. The Dual Zinc plus Arginine aqueous solution and dentifrice enhanced the barrier function of an in vitro gingival epithelium model as determined by a time-dependent increase in transepithelial electrical resistance and decrease in paracellular permeability. This was associated with an increased immunolabeling of two important tight junction proteins: zonula occludens-1 and occludin. The deleterious effects of P. gingivalis on keratinocyte barrier function as well as the ability of the bacterium to translocate through a gingival epithelium model were attenuated in the presence of either Dual Zinc plus Arginine aqueous solution or dentifrice. Conclusions The Dual Zinc plus Arginine formulation may offer benefits for patients affected by periodontal disease through its ability to attenuate the pathogenic properties of P. gingivalis and promote keratinocyte barrier function. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2000-2297 20002297 |
| Relation: | https://doaj.org/toc/2000-2297 |
| DOI: | 10.1080/20002297.2020.1798044 |
| URL الوصول: | https://doaj.org/article/0c2c4a5567b44c6189560a1616d5808b |
| رقم الانضمام: | edsdoj.0c2c4a5567b44c6189560a1616d5808b |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 20002297 |
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| DOI: | 10.1080/20002297.2020.1798044 |