Academic Journal
Blockade of Alternative Complement Pathway in Dense Deposit Disease
| العنوان: | Blockade of Alternative Complement Pathway in Dense Deposit Disease |
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| المؤلفون: | Aurore Berthe-Aucejo, Mathieu Sacquépée, Marc Fila, Michel Peuchmaur, Emilia Perrier-Cornet, Véronique Frémeaux-Bacchi, Georges Deschênes |
| المصدر: | Case Reports in Nephrology, Vol 2014 (2014) |
| بيانات النشر: | Hindawi Limited, 2014. |
| سنة النشر: | 2014 |
| المجموعة: | LCC:Diseases of the genitourinary system. Urology |
| مصطلحات موضوعية: | Diseases of the genitourinary system. Urology, RC870-923 |
| الوصف: | A patient aged 17 with dense deposit disease associated with complement activation, circulating C3 Nef, and Factor H mutation presented with nephrotic syndrome and hypertension. Steroid therapy, plasma exchange, and rituximab failed to improve proteinuria and hypertension despite a normalization of the circulating sC5b9 complex. Eculizumab, a monoclonal antibody directed against C5, was used to block the terminal product of the complement cascade. The dose was adapted to achieve a CH50 below 10%, but proteinuria and blood pressure were not improved after 3 months of treatment. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2090-6641 2090-665X |
| Relation: | https://doaj.org/toc/2090-6641; https://doaj.org/toc/2090-665X |
| DOI: | 10.1155/2014/201568 |
| URL الوصول: | https://doaj.org/article/e0bd678c202445d2bb60f003f2c337f7 |
| رقم الانضمام: | edsdoj.0bd678c202445d2bb60f003f2c337f7 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 20906641 2090665X |
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| DOI: | 10.1155/2014/201568 |