Academic Journal
Will extended field-of-view PET/CT depopulate the graveyard of failed PET radiopharmaceuticals?
| العنوان: | Will extended field-of-view PET/CT depopulate the graveyard of failed PET radiopharmaceuticals? |
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| المؤلفون: | E. F. J. de Vries, P. H. Elsinga, C. Tsoumpas |
| المصدر: | Cancer Imaging, Vol 22, Iss 1, Pp 1-7 (2022) |
| بيانات النشر: | BMC, 2022. |
| سنة النشر: | 2022 |
| المجموعة: | LCC:Medical physics. Medical radiology. Nuclear medicine LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens |
| مصطلحات موضوعية: | PET-radiopharmaceutical, Extended field of view, PET-camera, Sensitivity, Medical physics. Medical radiology. Nuclear medicine, R895-920, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282 |
| الوصف: | Abstract With the rapid emergence of extended Field-of-View PET-cameras several new applications for radiopharmaceuticals become within reach. Main reason is the significant increase of the sensitivity of the PET-camera so that much less radioactivity can be administered. Issues that that hampered development or use of PET-radiopharmaceuticals become realistic again. Molar activity requirements can become less strict. New low-yielding radiochemistry methods may become applicable. Carbon-11 labelled compounds can revive and potentially be shipped to nearby PET-facilities. PET-radiopharmaceuticals with slow kinetics in comparison to their half life can still be used. As additional infrastructure and equipment will likely remain unchanged and keep the same sensitivity therefore there will be issues with kinetic modelling requiring analysis of plasma or metabolites samples with lower count rate. Besides the potential revival of failed radiopharmaceuticals, novel challenges are ahead to develop novel radiochemistry based on thus far unsuitable (low yielding or time consuming) reactions. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1470-7330 |
| Relation: | https://doaj.org/toc/1470-7330 |
| DOI: | 10.1186/s40644-022-00510-1 |
| URL الوصول: | https://doaj.org/article/0b3ccb066cf04327b8653587b70489b4 |
| رقم الانضمام: | edsdoj.0b3ccb066cf04327b8653587b70489b4 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 14707330 |
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| DOI: | 10.1186/s40644-022-00510-1 |