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Role of some serum biomarkers in the early detection of diabetic cardiomyopathy

التفاصيل البيبلوغرافية
العنوان: Role of some serum biomarkers in the early detection of diabetic cardiomyopathy
المؤلفون: Amany H Abdelrahman, Iman I Salama, Somaia I Salama, Dalia M Elmosalami, Mona H Ibrahim, Eman M Hassan, Mark O Dimitry, Zahraa I Aboafya, Mohammad Gouda Mohammad, Mohamed Amin
المصدر: Future Science OA, Vol 7, Iss 5 (2021)
بيانات النشر: Taylor & Francis Group, 2021.
سنة النشر: 2021
المجموعة: LCC:Medicine
LCC:Medicine (General)
مصطلحات موضوعية: AGEs, diabetic cardiomyopathy, diastolic dysfunction, IGFBP-7, IL-6, insulin, Medicine, Medicine (General), R5-920
الوصف: Aim: To assess the role of serum biomarkers in early prediction of diabetic cardiomyopathy. Materials and methods: The participants were three groups of Type 2 diabetes mellitus (DM) patients having diastolic dysfunction (DM-DD), systolic dysfunction (DM-SD) and normal echocardiography (DM-N) with two control groups: non-DM diastolic dysfunction patients (DD) and healthy controls. AGEs, TNF-α, IL-6, IGFBP-7, creatinine and insulin were assessed. Results: TNF-α, AGEs, creatinine and insulin panel had area under the curve (AUC) of 0.913 in distinguishing DM-DD from DM-N (78.7% sensitivity and 100% specificity). IL-6 and AGEs panel had AUC 0.795 for differentiating DM-SD from DM-DD (90.6% sensitivity). IL-6, TNF-α and AGEs panel had AUC 0.924 for differentiating diabetic cardiomyopathy from DM-N (85% sensitivity and specificity). Conclusion: A panel of AGEs, IL-6, TNF-α, insulin and creatinine might be used for early detection of DM-DD among T2DM patients.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2056-5623
Relation: https://doaj.org/toc/2056-5623
DOI: 10.2144/fsoa-2020-0184
URL الوصول: https://doaj.org/article/0b1faa791aa843eeaf25b6a4bc164041
رقم الانضمام: edsdoj.0b1faa791aa843eeaf25b6a4bc164041
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:20565623
DOI:10.2144/fsoa-2020-0184