Academic Journal
Significance of infiltration of M1 tumor-associated macrophages in hepatocellular carcinoma
| العنوان: | Significance of infiltration of M1 tumor-associated macrophages in hepatocellular carcinoma |
|---|---|
| المؤلفون: | XIAO Feng, XU Tonglin, ZHU Lin, XIAO Jingwen, WU Tianqi, GU Chunyan |
| المصدر: | Zhongguo aizheng zazhi, Vol 34, Iss 8, Pp 726-733 (2024) |
| بيانات النشر: | Editorial Office of China Oncology, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens |
| مصطلحات موضوعية: | macrophage, programmed death ligand 1, hepatocellular carcinoma, prognosis, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282 |
| الوصف: | Background and purpose: Tumor-associated macrophages (TAM) as the main stromal cells in the tumor microenvironment play an important role in tumor progression. This study aimed to explore the clinical significance of M1 type TAM infiltration in hepatocellular carcinoma (HCC). Methods: We collected tissue paraffin samples from 320 HCC patients who underwent surgery at the Affiliated Nantong Hospital Three of Nantong University from January 2012 to December 2020. Immunohistochemical methods were used to detect the distribution of CD86 labeled M1 type TAM in HCC tissues, and positive cell density was calculated. Groups were established according to cell density, high-density group had cells with greater than average density (29 cells/mm2), and low-density group had cells with less than or equal to average density. The correlation and prognostic significance of M1 TAM density with clinicopathologic features and tumor infiltrating CD8＋ T lymphocytes of HCC were analyzed. Using immunohistochemistry to detect the expression of programmed death ligand-1 (PD-L1), the cases were divided into four groups based on the cell density of CD86 and PD-L1. In the CD86＋ high-density group, PD-L1 high-density (CD86highPD-L1high) and PD-L1 low-density (CD86highPD-L1low) groups were included. In the CD86＋ low-density group, the PD-L1 high-density (CD86lowPD-L1high) and PD-L1 low-density (CD86lowPD-L1low) groups were included. We analyzed the prognostic significance of CD86＋ M1 type TAM density combined with PD-L1 expression. This study was approved by the Ethics Committee of Affiliated Nantong Hospital Three of Nantong University (ethics number: EK2022005). Results: CD86＋ M1 type TAM was mainly distributed in the tumor stroma. Its high-density rate was 44.7% (143/320). The density of CD86＋ M1 type TAM was positively correlated with tumor infiltrating CD8＋ T lymphocyte density (P |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English Chinese |
| تدمد: | 1007-3639 |
| Relation: | http://www.china-oncology.com/fileup/1007-3639/PDF/1725946580969-13375267.pdf; https://doaj.org/toc/1007-3639 |
| DOI: | 10.19401/j.cnki.1007-3639.2024.08.002 |
| URL الوصول: | https://doaj.org/article/0aebeaf7db454c9fb8ee436ab658a2eb |
| رقم الانضمام: | edsdoj.0aebeaf7db454c9fb8ee436ab658a2eb |
| قاعدة البيانات: | Directory of Open Access Journals |
| تدمد: | 10073639 |
|---|---|
| DOI: | 10.19401/j.cnki.1007-3639.2024.08.002 |