Academic Journal
Exploration of the interaction between remote ischemic preconditioning and anesthetic-induced preconditioning using sevoflurane in isolated perfused rabbit heart
| العنوان: | Exploration of the interaction between remote ischemic preconditioning and anesthetic-induced preconditioning using sevoflurane in isolated perfused rabbit heart |
|---|---|
| المؤلفون: | Seung-Hee Yoo, Sooyoung Cho, Yoonsun Won, Jong Wha Lee |
| المصدر: | The Ewha Medical Journal, Vol 47, Iss 4 (2024) |
| بيانات النشر: | Ewha Womans University College of Medicine, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Medicine |
| مصطلحات موضوعية: | inhalation anesthesia, myocardial ischemic preconditioning, myocardial reperfusion injury, rabbits, sevoflurane, Medicine |
| الوصف: | Objectives: Remote ischemic preconditioning (rIPC) is a novel technique in which brief episodes of ischemia and reperfusion in one organ confer protection against prolonged ischemia in a distant organ. In contrast, anesthetic-induced preconditioning (APC) utilizes volatile anesthetics to protect multiple organs from ischemia-reperfusion injury. Both methods are easily integrated into various clinical scenarios for cardioprotection. However, it remains unclear whether simultaneous application of these techniques could result in complementary, additive, synergistic, or adverse effects. Methods: An adult rabbit heart Langendorff model of global ischemia/reperfusion injury was used to compare the cardioprotective effect of rIPC and APC alone and in combination relative to untreated (control) hearts. The rIPC group underwent four cycles of 5-minute ischemia on the hind limb, each followed by 5 minutes of reperfusion. The APC group received 2.5 vol% sevoflurane for 20 minutes via a face mask, followed by a 20-minute washout period. Results: Both in vivo rIPC, induced by four 5-minute cycles of ischemia/reperfusion on the hind limb, and APC, administered as 2.5 vol% sevoflurane via a mask, significantly reduced the size of myocardial infarction following 30 minutes of global ischemia by >50% compared to the untreated control group (rIPC, 12.1±1.7%; APC, 13.5±2.1%; P |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English Korean |
| تدمد: | 2234-2591 |
| Relation: | http://www.e-emj.org/archive/view_article?pid=emj-47-4-61; https://doaj.org/toc/2234-2591 |
| DOI: | 10.12771/emj.2024.e68 |
| URL الوصول: | https://doaj.org/article/09fe0d57ec4a4e08afbe966c9d2c80d7 |
| رقم الانضمام: | edsdoj.09fe0d57ec4a4e08afbe966c9d2c80d7 |
| قاعدة البيانات: | Directory of Open Access Journals |
| تدمد: | 22342591 |
|---|---|
| DOI: | 10.12771/emj.2024.e68 |