التفاصيل البيبلوغرافية
| العنوان: |
Validation of the stratification for newly diagnosed hepatoblastoma: An analysis from the Children’s Hepatic tumors International Collaboration (CHIC) database |
| المؤلفون: |
Arun A. Rangaswami, Angela D. Trobaugh-Lotrario, Rudolf Maibach, Allison F. O’Neill, Daniel C. Aronson, Rebecka L. Meyers, Mark D. Krailo, Jin Piao, Eiso Hiyama, Tomoro Hishiki, Marc Ansari, Dolores Lopez-Terrada, Piotr Czauderna, Marcio Malogolowkin, Beate Häberle |
| المصدر: |
EJC Paediatric Oncology, Vol 5, Iss , Pp 100206- (2025) |
| بيانات النشر: |
Elsevier, 2025. |
| سنة النشر: |
2025 |
| المجموعة: |
LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens |
| مصطلحات موضوعية: |
Hepatoblastoma, Risk stratification, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282 |
| الوصف: |
Introduction: The Children’s Hepatic Tumors International Collaboration (CHIC) previously developed the CHIC hepatoblastoma risk stratification (CHIC-HS) model by analyzing the original CHIC dataset (development set). A validation of the results was planned with data from contemporary trials that were ongoing at the time of the initial analysis. Material and methods: Subsequent analysis was performed on the contemporary trials (validation set) SIOPEL 4, SIOPEL 6, COG AHEP0731, and JPLT 2 (2011–2013 cohort) utilizing the same methodology as in the CHIC-HS development. Results: 403 patients were available for analysis for validation of the CHIC-HS model. Clinical characteristics were comparable between the validation and development sets. Event free survival (EFS) was similar in the very low and low-risk CHIC-HS strata in both the development and validation sets. EFS was higher in the intermediate and high-risk strata in the validation set as compared with the development set consistent with improved survival of intermediate-risk patients on AHEP0731 and high-risk patients on SIOPEL 4. Conclusions: The four risk groups in the CHIC-HS retain their relevance for risk stratification in this analysis, notwithstanding improved outcomes in patients with higher risk hepatoblastoma; therefore, the CHIC-HS remains a valid model which differentiates patients into statistically distinct risk strata. The model will be further evaluated with data from the current pediatric international hepatic tumors trial (PHITT). |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
2772-610X |
| Relation: |
http://www.sciencedirect.com/science/article/pii/S2772610X24000667; https://doaj.org/toc/2772-610X |
| DOI: |
10.1016/j.ejcped.2024.100206 |
| URL الوصول: |
https://doaj.org/article/ee09da668f204d3b8900290732495200 |
| رقم الانضمام: |
edsdoj.09da668f204d3b8900290732495200 |
| قاعدة البيانات: |
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