التفاصيل البيبلوغرافية
| العنوان: |
Autoantibodies in COVID-19: implications for disease severity and clinical outcomes |
| المؤلفون: |
Yannick Galipeau, Curtis Cooper, Marc-André Langlois |
| المصدر: |
Frontiers in Immunology, Vol 15 (2025) |
| بيانات النشر: |
Frontiers Media S.A., 2025. |
| سنة النشر: |
2025 |
| المجموعة: |
LCC:Immunologic diseases. Allergy |
| مصطلحات موضوعية: |
SARS-CoV-2, COVID-19, autoantibodies, ACE2, autoimmunity, long-COVID, Immunologic diseases. Allergy, RC581-607 |
| الوصف: |
Few pathogens have historically been subjected to as intense scientific and clinical scrutiny as SARS-CoV-2. The genetic, immunological, and environmental factors influencing disease severity and post-infection clinical outcomes, known as correlates of immunity, remain largely undefined. Clinical outcomes of SARS-CoV-2 infection vary widely, ranging from asymptomatic cases to those with life-threatening COVID-19 symptoms. While most infected individuals return to their former health and fitness within a few weeks, some develop debilitating chronic symptoms, referred to as long-COVID. Autoimmune responses have been proposed as one of the factors influencing long-COVID and the severity of SARS-CoV-2 infection. The association between viral infections and autoimmune pathologies is not new. Viruses such as Epstein-Barr virus and cytomegalovirus, among others, have been shown to induce the production of autoantibodies and the onset of autoimmune conditions. Given the extensive literature on SARS-CoV-2, here we review current evidence on SARS-CoV-2-induced autoimmune pathologies, with a focus on autoantibodies. We closely examine mechanisms driving autoantibody production, particularly their connection with disease severity and long-COVID. |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
1664-3224 |
| Relation: |
https://www.frontiersin.org/articles/10.3389/fimmu.2024.1509289/full; https://doaj.org/toc/1664-3224 |
| DOI: |
10.3389/fimmu.2024.1509289 |
| URL الوصول: |
https://doaj.org/article/09b164d5f58746a4989056dce00744f3 |
| رقم الانضمام: |
edsdoj.09b164d5f58746a4989056dce00744f3 |
| قاعدة البيانات: |
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