Academic Journal
Phenotypic characterization of Macrolide-Lincosamide-Streptogramin B resistance in Staphylococcus aureus
| العنوان: | Phenotypic characterization of Macrolide-Lincosamide-Streptogramin B resistance in Staphylococcus aureus |
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| المؤلفون: | Giridhar Kumar Modukuru, Pradeep Madala Sobhana Surya, Vishnuvardhana Rao Kakumanu, Saritha Yarava |
| المصدر: | Journal of Pure and Applied Microbiology, Vol 15, Iss 2, Pp 689-694 (2021) |
| بيانات النشر: | Journal of Pure and Applied Microbiology, 2021. |
| سنة النشر: | 2021 |
| المجموعة: | LCC:Microbiology |
| مصطلحات موضوعية: | staphylococcus aureus, mrsa, mssa, d-test, inducible clindamycin resistance, mlsb phenotypes, Microbiology, QR1-502 |
| الوصف: | Staphylococcus aureus (S.aureus) is a prevalent organism causing infections in the community and hospital. A variety of antibiotics are used, including the Macrolide-Lincosamide-StreptograminB (MLSB) family of antibiotics in which clindamycin is the preferred agent. Widespread use of these antibiotics leads to resistance to these MLSB antibiotics; a D-test can characterize the different MLSB phenotypes. This study was taken up with an objective to perform a double disc diffusion test for detecting different phenotypes in S.aureus with particular reference to inducible clindamycin resistance. Out of a total of 174(100%) strains of S.aureus, 98(56.32%) were MRSA, and 76(43.68%) were MSSA. All isolates were tested by D-test. A total of 47(27.01%) were of cMLSB phenotype, 31(17.82%) were of iMLSB phenotype, and 96(55.17%) were of MS phenotype. The majority of MRSA strains were cMLSB phenotype(76.60%) and iMLSB phenotype (64.52%) in comparison to MSSA isolates. Although iMLSB phenotypes are present in both MRSA and MSSA, iMLSB was more in MRSA isolates. Appropriate susceptibility data is essential for a clinician to start clindamycin therapy to prevent therapeutic failures with inducible MLSB resistance in S.aureus isolates. It will be appropriate for all the clinical laboratories to report inducible Clindamycin resistance in S.aureus strains (both MRSA and MSSA), for which D-test is a reliable testing method. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 0973-7510 2581-690X |
| Relation: | https://microbiologyjournal.org/phenotypic-characterization-of-macrolide-lincosamide-streptogramin-b-resistance-in-staphylococcus-aureus/; https://doaj.org/toc/0973-7510; https://doaj.org/toc/2581-690X |
| DOI: | 10.22207/JPAM.15.2.18 |
| URL الوصول: | https://doaj.org/article/a0957dd2caa242bea0426aa18386b317 |
| رقم الانضمام: | edsdoj.0957dd2caa242bea0426aa18386b317 |
| قاعدة البيانات: | Directory of Open Access Journals |
| تدمد: | 09737510 2581690X |
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| DOI: | 10.22207/JPAM.15.2.18 |