Academic Journal
The Relevance of Anti-PF4 Antibody Isotypes and Endogenous Glycosaminoglycans and their Relationship with Inflammatory Biomarkers in Pulmonary Embolism Patients
| العنوان: | The Relevance of Anti-PF4 Antibody Isotypes and Endogenous Glycosaminoglycans and their Relationship with Inflammatory Biomarkers in Pulmonary Embolism Patients |
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| المؤلفون: | Bulent Kantarcioglu MD, Amir Darki MD, MSc, Fakiha Siddiqui BDS, Debra Hoppensteadt PhD, Joseph Lewis BA, Roland Krämer PhD, Cafer Adiguzel MD, Jawed Fareed PhD |
| المصدر: | Clinical and Applied Thrombosis/Hemostasis, Vol 28 (2022) |
| بيانات النشر: | SAGE Publishing, 2022. |
| سنة النشر: | 2022 |
| المجموعة: | LCC:Diseases of the circulatory (Cardiovascular) system |
| مصطلحات موضوعية: | Diseases of the circulatory (Cardiovascular) system, RC666-701 |
| الوصف: | Introduction Previous studies have shown that inflammation may contribute to the interplay of endogenous glycosaminoglycans (GAGs) and anti-PF4 antibodies. In this study, we quantified the levels of anti-PF4 antibody isotypes and endogenous GAGs together with inflammatory biomarkers in pulmonary embolism (PE) patients to determine whether there is a relationship in between. Identification of this relationship may provide insight to the complex pathophysiology of PE and HIT and may also be useful for development of potential prognostic, diagnostic and therapeutic interventions. Materials and Methods Plasma samples from PE patients (n: 210) were analyzed for anti-PF4 antibody isotypes and various thrombo-inflammatory cytokines utilizing commercially available biochip array and ELISA methods. The endogenous GAG levels in PE patients’ plasma were quantified using a fluorescence quenching method. The collected data analyzed to demonstrate the relationship between various parameters. Results The endogenous GAG levels were increased in the PE group ( P |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1938-2723 10760296 |
| Relation: | https://doaj.org/toc/1938-2723 |
| DOI: | 10.1177/10760296221091770 |
| URL الوصول: | https://doaj.org/article/0925d3dd1a314087b13744d52f7659ec |
| رقم الانضمام: | edsdoj.0925d3dd1a314087b13744d52f7659ec |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 19382723 10760296 |
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| DOI: | 10.1177/10760296221091770 |