Academic Journal
Are COVID-19 Polymorphisms in ACE and ACE2 Prognosis Predictors?
| العنوان: | Are COVID-19 Polymorphisms in ACE and ACE2 Prognosis Predictors? |
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| المؤلفون: | Fabiana Amaral Guarienti, Fernando Antônio Costa Xavier, Mateus Duarte Ferraz, Fernanda Wagner, Daniel Rodrigo Marinowic, Jaderson Costa da Costa, Denise Cantarelli Machado |
| المصدر: | Current Issues in Molecular Biology, Vol 46, Iss 8, Pp 8111-8117 (2024) |
| بيانات النشر: | MDPI AG, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Biology (General) |
| مصطلحات موضوعية: | polymorphism, COVID-19, ACE, prognosis, SARS-CoV-2, Biology (General), QH301-705.5 |
| الوصف: | Regardless of the containment of the SARS-CoV-2 pandemic, it remains paramount to comprehensively understand its underlying mechanisms to mitigate potential future health and economic impacts, comparable to those experienced throughout the course of the pandemic. The angiotensin-converting enzyme 2 (ACE2) provides anchorage for SARS-CoV-2 binding, thus implicating that ACE and ACE2 might contribute to the variability in infection severity. This study aimed to elucidate predisposing factors influencing the disease course among people infected by SARS-CoV-2, focusing on angiotensin-converting enzyme (ACE) and ACE2 polymorphisms. Notably, despite similar demographics and comorbidities, COVID-19 patients exhibit substantial differences in prognosis. Genetic polymorphisms in ACE and ACE2 have been implicated in disease progression, prompting our investigation into their role in COVID-19 evolution. Using next-generation sequencing (NGS), we analyzed ACE and ACE2 genes in a sample group comprising six subjects infected by SARS-CoV-2. Our findings revealed a correlation between specific polymorphisms and COVID-19 outcomes. Specifically, ACE and ACE2 intronic deletions were observed in all deceased patients, suggesting a potential association with mortality. These results highlight the significance of genetic factors in shaping the clinical course of COVID-19, emphasizing the importance of further research into the impact of genetic variations on COVID-19 severity. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1467-3045 1467-3037 |
| Relation: | https://www.mdpi.com/1467-3045/46/8/480; https://doaj.org/toc/1467-3037; https://doaj.org/toc/1467-3045 |
| DOI: | 10.3390/cimb46080480 |
| URL الوصول: | https://doaj.org/article/091ebe7b3c004851a7ebfe22ab96184c |
| رقم الانضمام: | edsdoj.091ebe7b3c004851a7ebfe22ab96184c |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 14673045 14673037 |
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| DOI: | 10.3390/cimb46080480 |