Academic Journal
Seroepidemiology of pertussis immunity in five provinces of China: A population-based, cross-sectional study
| العنوان: | Seroepidemiology of pertussis immunity in five provinces of China: A population-based, cross-sectional study |
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| المؤلفون: | Zhujiazi Zhang, Qing Wang, Qi Zhu, Shuang Bai, Yang Liu, Jia Ren, Xin Xu, Jiangwen Qu, Jingbin Pan, Li Lu, Luodan Suo, Xiaodong Sun, Ying Zhang, Jiang Wu |
| المصدر: | Human Vaccines & Immunotherapeutics, Vol 20, Iss 1 (2024) |
| بيانات النشر: | Taylor & Francis Group, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Immunologic diseases. Allergy LCC:Therapeutics. Pharmacology |
| مصطلحات موضوعية: | Pertussis, anti-FHA IgG, anti-PT IgA, anti-PT IgG, seroepidemiology, vaccines, Immunologic diseases. Allergy, RC581-607, Therapeutics. Pharmacology, RM1-950 |
| الوصف: | This study aimed to evaluate the seroprevalence of Bordetella pertussis and persistence of antibodies following vaccination. We recruited 6060 healthy subjects from five provinces of China during 2017–2018. Serum IgG antibodies against pertussis toxin (anti-PT IgG) and filamentous hemagglutinin (anti-FHA IgG), and serum IgA antibodies against pertussis toxin (anti-PT IgA) were measured by ELISA. Geometric mean concentration (GMC), seropositivity rate, and recent infection rate were calculated. Among 0–6 years-olds, the anti-PT IgG, anti-PT IgA, and anti-FHA IgG GMCs were 6.4 IU/ml (95% CI 6.1–6.8), 2.8 IU/ml (95% CI 2.7–2.8), and 13.3 IU/ml (95% CI 12.4–14.2), respectively. The anti-PT IgG GMC increased in accordance with the primary vaccination series (4–6 months) and the toddler booster (18–24 months), but declined thereafter through to age 5 years [4.7 IU/ml (95% CI 4.2–5.4)]. The seropositivity rate of pertussis in >6 year-olds was 9.0% (95% CI 8.1–9.9) and the recent infection rate was 3.3% (95% CI, 2.7–3.8). Recent infection rate began to increase from 6 years of age, with peaks at 9, 20, 40, and ≥60 years of age. The anti-PT IgG GMCs of children aged 0–6 years who were vaccinated with DTaP, DTaP-IPV//PRP～T, and DTaP-Hib were 5.9 IU/ml (95% CI 5.6–6.3), 20.7 IU/ml (95% CI 15.6–27.8), and 11.7 IU/ml (95% CI 7.5–18.1) (p |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 21645515 2164-554X 2164-5515 |
| Relation: | https://doaj.org/toc/2164-5515; https://doaj.org/toc/2164-554X |
| DOI: | 10.1080/21645515.2024.2417532 |
| URL الوصول: | https://doaj.org/article/c08b69d559634cc4b09316308f3821c3 |
| رقم الانضمام: | edsdoj.08b69d559634cc4b09316308f3821c3 |
| قاعدة البيانات: | Directory of Open Access Journals |
| تدمد: | 21645515 2164554X |
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| DOI: | 10.1080/21645515.2024.2417532 |