التفاصيل البيبلوغرافية
| العنوان: |
Pre-pregnancy Maternal Weight and Gestational Weight Gain Increase the Risk for Childhood Asthma and Wheeze: An Updated Meta-Analysis |
| المؤلفون: |
Shufang Liu, Bo Zhou, Yunfeng Wang, Kundi Wang, Zhixin Zhang, Wenquan Niu |
| المصدر: |
Frontiers in Pediatrics, Vol 8 (2020) |
| بيانات النشر: |
Frontiers Media S.A., 2020. |
| سنة النشر: |
2020 |
| المجموعة: |
LCC:Pediatrics |
| مصطلحات موضوعية: |
asthma, gestational weight gain, meta-analysis, maternal obesity, maternal overweight, Pediatrics, RJ1-570 |
| الوصف: |
Background: Mounting evidence suggests that childhood asthma is closely associated with maternal weight before pregnancy and gestational weight gain (GWG), yet the results are not often reproducible.Objectives: We conducted a comprehensive meta-analysis, aiming to evaluate the association of pre-pregnancy maternal obesity or overweight and high GWG with the risk for childhood asthma and wheeze.Methods: Literature search, quality assessment, and data extraction were completed independently and in duplicate. Effect-size estimates are expressed as odds ratio (OR) with 95% confidence interval (CI).Results: Twenty-two observational studies involving 145,574 mother-child pairs were meta-analyzed. In overall analyses, maternal obesity or overweight in pre-pregnancy significantly increased the risk of both childhood asthma and wheeze (adjusted OR: 1.41 and 1.13, 95% CI: 1.26–1.59 and 1.07–1.20, both p < 0.001). Per 1 kg/m2 increment in maternal body mass index was associated with a significantly increased risk of childhood asthma and wheeze (adjusted OR: 1.03, 95% CI: 1.02-1.03, p < 0.001). Compared with normal GWG, very high GWG (adjusted OR: 1.24, 95% CI: 1.04-1.47, p: 0.018), moderate high GWG (adjusted OR: 1.12, 95% CI: 1.04-1.21, p: 0.004), and very low GWG (adjusted OR: 1.26, 95% CI: 1.08-1.47, p: 0.004) increased the risk of childhood asthma and wheeze. There was a low probability of publication bias.Conclusions: Our findings indicate that both pre-pregnancy maternal obesity or overweight and very to moderate high or low GWG render their offspring susceptible to a significantly increased risk of having childhood asthma and wheeze. |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
2296-2360 |
| Relation: |
https://www.frontiersin.org/article/10.3389/fped.2020.00134/full; https://doaj.org/toc/2296-2360 |
| DOI: |
10.3389/fped.2020.00134 |
| URL الوصول: |
https://doaj.org/article/0871d569c27d4858aed8c89226b16dce |
| رقم الانضمام: |
edsdoj.0871d569c27d4858aed8c89226b16dce |
| قاعدة البيانات: |
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