Academic Journal
(1R,2S,5R)-5-Methyl-2-(propan-2-yl)cyclohexyl 4-amino-3-phenylbutanoate hydrochloride: Synthesis and anticonvulsant activity
| العنوان: | (1R,2S,5R)-5-Methyl-2-(propan-2-yl)cyclohexyl 4-amino-3-phenylbutanoate hydrochloride: Synthesis and anticonvulsant activity |
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| المؤلفون: | Nesterkina Mariia, Musatov Vladimir, Honcharova Olena, Kravchenko Iryna |
| المصدر: | Open Chemistry, Vol 20, Iss 1, Pp 703-707 (2022) |
| بيانات النشر: | De Gruyter, 2022. |
| سنة النشر: | 2022 |
| المجموعة: | LCC:Chemistry |
| مصطلحات موضوعية: | ester, l-menthol, phenibut, terpenoid, anticonvulsant activity, steglich esterification, Chemistry, QD1-999 |
| الوصف: | Ester based on l-menthol and phenibut ‒ (1R,2S,5R)-5-methyl-2-(propan-2-yl)cyclohexyl 4-amino-3-phenylbutanoate hydrochloride was obtained in 78% yield using N,N′-dicyclohexylcarbodiimide as a coupling reagent along with catalytic amount of 4-dimethylaminopyridine. The obtained product was characterized by FT-IR, fast-atom bombardment-mass spectrometry along with 1H-NMR and 13C-NMR spectral analysis; the purity was assessed using high-performance liquid chromatography. Phenibut ester has been examined on the models of chemically- and electrically-induced seizures for potential anticonvulsant profile. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2391-5420 2022-0189 |
| Relation: | https://doaj.org/toc/2391-5420 |
| DOI: | 10.1515/chem-2022-0189 |
| URL الوصول: | https://doaj.org/article/a068a88b3bb84af1990c1370b525cf9b |
| رقم الانضمام: | edsdoj.068a88b3bb84af1990c1370b525cf9b |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 23915420 20220189 |
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| DOI: | 10.1515/chem-2022-0189 |