التفاصيل البيبلوغرافية
| العنوان: |
Multivalent mRNA Vaccine Elicits Broad Protection against SARS-CoV-2 Variants of Concern |
| المؤلفون: |
Monika Kumari, Kang-Hao Liang, Shih-Chieh Su, Hsiu-Ting Lin, Yu-Feng Lu, Ming-Jane Wu, Wan-Yu Chen, Han-Chung Wu |
| المصدر: |
Vaccines, Vol 12, Iss 7, p 714 (2024) |
| بيانات النشر: |
MDPI AG, 2024. |
| سنة النشر: |
2024 |
| المجموعة: |
LCC:Medicine |
| مصطلحات موضوعية: |
SARS-CoV-2, variants of concern, multivalent mRNA vaccines, vaccine efficacy, Medicine |
| الوصف: |
SARS-CoV-2 new waves are primarily caused by changes to the spike protein (S), which can substantially decrease the efficacy of vaccines. Therefore, we tested several multivalent mRNA-LNP vaccines, targeting the full-length S proteins of different variants, and identified an optimal combination for protection against VOCs in BALB/c mice. The tested formulations included trivalent (WT + BA.5 + XBB.1.5), pentavalent (WT + BA.5 + XBB.1.5 + BQ.1.1 + CH.1.1), and octavalent (WT + BA.5 + XBB.1.5 + BQ.1.1 + CH.1.1 + Alpha + Delta + BA.2) vaccines. Among these multivalent vaccines, the pentavalent vaccine showed superior protection for almost all tested variants. Despite this, each multivalent vaccine elicited greater broad-spectrum neutralizing antibodies than the previously evaluated bivalent vaccine (WT + BA.5). Subsequently, we redesigned the multivalent vaccine to efficiently generate neutralizing antibodies against recent VOCs, including EG.5.1. Immunization with the redesigned pentavalent vaccine (WT + EG.5.1 + XBB.1.16 + Delta + BA.5) showed moderate levels of protection against recent Omicron VOCs. Results suggest that the neutralization activity of multivalent vaccines is better than those of the tested bivalent vaccines against WT + BA.5 and WT + EG.5.1. Moreover, the pentavalent vaccine we developed may be highly useful for neutralizing new Omicron VOCs. |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
2076-393X |
| Relation: |
https://www.mdpi.com/2076-393X/12/7/714; https://doaj.org/toc/2076-393X |
| DOI: |
10.3390/vaccines12070714 |
| URL الوصول: |
https://doaj.org/article/065a807d43ca4f63bb9b8eec1855c9e7 |
| رقم الانضمام: |
edsdoj.065a807d43ca4f63bb9b8eec1855c9e7 |
| قاعدة البيانات: |
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