التفاصيل البيبلوغرافية
| العنوان: |
Pan-cancer analysis of m1A writer gene RRP8: implications for immune infiltration and prognosis in human cancers |
| المؤلفون: |
Zhihui Huang, Koo Han Yoo, Duohui Li, Qingxin Yu, Luxia Ye, Wuran Wei |
| المصدر: |
Discover Oncology, Vol 15, Iss 1, Pp 1-16 (2024) |
| بيانات النشر: |
Springer, 2024. |
| سنة النشر: |
2024 |
| المجموعة: |
LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens |
| مصطلحات موضوعية: |
Pan cancer, RNA 1-methylcytosine, Ribosomal RNA Processing 8, Tumor-infiltrating cells, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282 |
| الوصف: |
Abstract Background Ribosomal RNA Processing 8 (RRP8) is a gene associated with RNA modification and has been implicated in the development of several types of tumors in recent research. Nevertheless, the biological importance of RRP8 in pan-cancer has not yet been thoroughly and comprehensively investigated. Methods In this study, we conducted an analysis of various public databases to investigate the biological functions of RRP8. Our analysis included examining its correlation with pan-cancer prognosis, heterogeneity, stemness, immune checkpoint genes, and immune cell infiltration. Furthermore, we utilized the GDSC and CTRP databases to assess the sensitivity of RRP8 to small molecule drugs. Results Our findings indicate that RRP8 exhibits differential expression between tumor and normal samples, particularly impacting the prognosis of various cancers such as Adrenocortical carcinoma (ACC) and Kidney Chromophobe (KICH). The expression of RRP8 is intricately linked to tumor heterogeneity and stemness markers. Additionally, RRP8 shows a positive correlation with the presence of tumor-infiltrating cells, with TP53 being the predominant mutated gene in these malignancies. Conclusion Our findings suggest that RRP8 may serve as a potential prognostic marker and therapeutic target in a variety of cancer types. |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
2730-6011 |
| Relation: |
https://doaj.org/toc/2730-6011 |
| DOI: |
10.1007/s12672-024-01299-0 |
| URL الوصول: |
https://doaj.org/article/a06204a739af47478fa7ba76de77e1c0 |
| رقم الانضمام: |
edsdoj.06204a739af47478fa7ba76de77e1c0 |
| قاعدة البيانات: |
Directory of Open Access Journals |
Full Text Finder