التفاصيل البيبلوغرافية
| العنوان: |
A 3D-Printed Modular Microreservoir for Drug Delivery |
| المؤلفون: |
Farzad Forouzandeh, Nuzhet N. Ahamed, Meng-Chun Hsu, Joseph P. Walton, Robert D. Frisina, David A. Borkholder |
| المصدر: |
Micromachines, Vol 11, Iss 7, p 648 (2020) |
| بيانات النشر: |
MDPI AG, 2020. |
| سنة النشر: |
2020 |
| المجموعة: |
LCC:Mechanical engineering and machinery |
| مصطلحات موضوعية: |
modular microfluidics, drug delivery, microreservoir, implantable, transdermal, 3D-printing, Mechanical engineering and machinery, TJ1-1570 |
| الوصف: |
Reservoir-based drug delivery microsystems have enabled novel and effective drug delivery concepts in recent decades. These systems typically comprise integrated storing and pumping components. Here we present a stand-alone, modular, thin, scalable, and refillable microreservoir platform as a storing component of these microsystems for implantable and transdermal drug delivery. Three microreservoir capacities (1, 10, and 100 µL) were fabricated with 3 mm overall thickness using stereolithography 3D-printing technology, enabling the fabrication of the device structure comprising a storing area and a refill port. A thin, preformed dome-shaped storing membrane was created by the deposition of parylene-C over a polyethylene glycol sacrificial layer, creating a force-free membrane that causes zero forward flow and insignificant backward flow (2% of total volume) due to membrane force. A septum pre-compression concept was introduced that enabled the realization of a 1-mm-thick septa capable of ~65000 leak-free refill punctures under 100 kPa backpressure. The force-free storing membrane enables using normally-open micropumps for drug delivery, and potentially improves the efficiency and precision of normally-closed micropumps. The ultra-thin septum reduces the thickness of refillable drug delivery devices, and is capable of thousands of leak-free refills. This modular and scalable device can be used for drug delivery in different laboratory animals and humans, as a sampling device, and for lab-on-a-chip and point-of-care diagnostics applications. |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
2072-666X |
| Relation: |
https://www.mdpi.com/2072-666X/11/7/648; https://doaj.org/toc/2072-666X |
| DOI: |
10.3390/mi11070648 |
| URL الوصول: |
https://doaj.org/article/d061f8a88d614c2bbdb1d6962ef85299 |
| رقم الانضمام: |
edsdoj.061f8a88d614c2bbdb1d6962ef85299 |
| قاعدة البيانات: |
Directory of Open Access Journals |
Full Text Finder