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The transformation suppressor gene Reck is required for postaxial patterning in mouse forelimbs

التفاصيل البيبلوغرافية
العنوان: The transformation suppressor gene Reck is required for postaxial patterning in mouse forelimbs
المؤلفون: Mako Yamamoto, Tomoko Matsuzaki, Rei Takahashi, Eijiro Adachi, Yasuhiro Maeda, Sachiyo Yamaguchi, Hitoshi Kitayama, Michiko Echizenya, Yoko Morioka, David B. Alexander, Takeshi Yagi, Shigeyoshi Itohara, Takashi Nakamura, Haruhiko Akiyama, Makoto Noda
المصدر: Biology Open, Vol 1, Iss 5, Pp 458-466 (2012)
بيانات النشر: The Company of Biologists, 2012.
سنة النشر: 2012
المجموعة: LCC:Science
LCC:Biology (General)
مصطلحات موضوعية: Mouse, Reck, Wnt7a, Limb patterning, Cutaneous horn, Teratogens, Science, Biology (General), QH301-705.5
الوصف: Summary The membrane-anchored metalloproteinase-regulator RECK has been characterized as a tumor suppressor. Here we report that mice with reduced Reck-expression show limb abnormalities including right-dominant, forelimb-specific defects in postaxial skeletal elements. The forelimb buds of low-Reck mutants have an altered dorsal ectoderm with reduced Wnt7a and Igf2 expression, and hypotrophy in two signaling centers (i.e., ZPA and AER) that are essential for limb outgrowth and patterning. Reck is abundantly expressed in the anterior mesenchyme in normal limb buds; mesenchyme-specific Reck inactivation recapitulates the low-Reck phenotype; and some teratogens downregulate Reck in mesenchymal cells. Our findings illustrate a role for Reck in the mesenchymal-epithelial interactions essential for mammalian development.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2046-6390
Relation: http://bio.biologists.org/content/1/5/458; https://doaj.org/toc/2046-6390
DOI: 10.1242/bio.2012638
URL الوصول: https://doaj.org/article/05bdff7d5569489aa6c03123778533b7
رقم الانضمام: edsdoj.05bdff7d5569489aa6c03123778533b7
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:20466390
DOI:10.1242/bio.2012638