التفاصيل البيبلوغرافية
| العنوان: |
Age-based factors modulating the required thyroxine dose to achieve thyrotropin suppression in intermediate-and high-risk papillary thyroid cancer |
| المؤلفون: |
Ruo-Yun Zhou, Ning Li, Hai-Long Tan, Neng Tang, Pei Chen, Mian Liu, Deng-Jie Ou-Yang, Zi-En Qin, Lei Ai, Bo Wei, Ya-Xin Zhao, Shi Chang, Peng Huang |
| المصدر: |
Frontiers in Endocrinology, Vol 14 (2023) |
| بيانات النشر: |
Frontiers Media S.A., 2023. |
| سنة النشر: |
2023 |
| المجموعة: |
LCC:Diseases of the endocrine glands. Clinical endocrinology |
| مصطلحات موضوعية: |
thyrotropin suppression, intermediate-and high-risk differentiated thyroid cancer, individualized medication regimens, age stratification, thyroid cancer, Diseases of the endocrine glands. Clinical endocrinology, RC648-665 |
| الوصف: |
BackgroundGuidelines widely recommend thyrotropin suppression to reduce the risk of recurrence in intermediate- and high-risk papillary thyroid cancer (PTC) after total thyroidectomy. However, an insufficient or excessive dosage may result in a number of symptoms/complications especially in older patients.Patients and methodsWe constructed a retrospective cohort including 551 PTC patient encounters. Using propensity score matching and logistic regression models, we determined the independent risk factors affecting levothyroxine therapy at different ages. Our outcomes included: expected TSH level and an unexpected TSH level, which was based on the initial thyroid-stimulating hormone (TSH) goal< 0.1 mIU/L with usual dosage of L-T4 (1.6 μg/kg/day).ResultsFrom our analysis, more than 70% of patients undergoing total thyroidectomy did not achieve the expected TSH level using an empirical medication regimen, and the effect of the drug was affected by age (odds ratio [OR], 1.063; 95% CI, 1.032-1.094), preoperative TSH level (OR, 0.554; 95% CI, 0.436-0.704) and preoperative fT3 level (OR, 0.820; 95% CI, 0.727-0.925). In patients with age < 55 years old, preoperative TSH level (OR, 0.588; 95% CI, 0.459-0.753), and preoperative fT3 level (OR, 0.859; 95% CI, 0.746-0.990) were two independent protective factors, while, in patients with age ≥ 55 years old, only preoperative TSH level (OR, 0.490; 95% CI, 0.278-0.861) was the independent protective factors to achieve expected TSH level.ConclusionOur retrospective analysis suggested the following significant risk factors of getting TSH suppression in PTC patients: age (≥55 years), lower preoperative TSH and fT3 levels. |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
1664-2392 |
| Relation: |
https://www.frontiersin.org/articles/10.3389/fendo.2023.1126592/full; https://doaj.org/toc/1664-2392 |
| DOI: |
10.3389/fendo.2023.1126592 |
| URL الوصول: |
https://doaj.org/article/055adfb10f7b4208b9c47f6feda2b696 |
| رقم الانضمام: |
edsdoj.055adfb10f7b4208b9c47f6feda2b696 |
| قاعدة البيانات: |
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