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Regulatory role of short-chain fatty acids in inflammatory bowel disease

التفاصيل البيبلوغرافية
العنوان: Regulatory role of short-chain fatty acids in inflammatory bowel disease
المؤلفون: Zhilin Zhang, Huan Zhang, Tian Chen, Lin Shi, Daorong Wang, Dong Tang
المصدر: Cell Communication and Signaling, Vol 20, Iss 1, Pp 1-10 (2022)
بيانات النشر: BMC, 2022.
سنة النشر: 2022
المجموعة: LCC:Medicine
LCC:Cytology
مصطلحات موضوعية: Inflammatory bowel disease, Immunomodulating activity, Therapeutic effects, Short-chain fatty acids, Gut microbiota, Medicine, Cytology, QH573-671
الوصف: Abstract Inflammatory bowel disease (IBD) comprises a group of chronic inflammatory disorders of the gastrointestinal tract. Accumulating evidence shows that the development of IBD is always accompanied by the dysbiosis of the gut microbiota (GM), causing a decrease in prebiotic levels and an increase in harmful metabolite levels. This leads to persistent immune response and inflammation in the intestine, greatly impairing the physiological function of the gastrointestinal tract. Short-chain fatty acids (SCFAs) are produced by probiotic gut bacteria from a fiber-rich diet that cannot be digested directly. SCFAs with significant anti-inflammatory functions regulate immune function and prevent an excessive immune response, thereby delaying the clinical progression of IBD. In this review, we summarize the generation of SCFAs and their potential therapeutic effects on IBD. Furthermore, we suggest that SCFAs may modulate innate immune recognition and cytokine production to intervene in the progression of IBD. Additional randomized controlled trials and prospective cohort studies should also investigate the clinical impact of SCFA. Video Abstract
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1478-811X
Relation: https://doaj.org/toc/1478-811X
DOI: 10.1186/s12964-022-00869-5
URL الوصول: https://doaj.org/article/d0517928aa0c4efbb5353076f1f9b65c
رقم الانضمام: edsdoj.0517928aa0c4efbb5353076f1f9b65c
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:1478811X
DOI:10.1186/s12964-022-00869-5