التفاصيل البيبلوغرافية
| العنوان: |
Anesthetic drugs modulate feeding behavior and hypothalamic expression of the POMC polypeptide precursor and the NPY neuropeptide |
| المؤلفون: |
E. Besnier, T. Clavier, M. C. Tonon, G. Pelletier, B. Dureuil, H. Castel, V. Compère |
| المصدر: |
BMC Anesthesiology, Vol 18, Iss 1, Pp 1-7 (2018) |
| بيانات النشر: |
BMC, 2018. |
| سنة النشر: |
2018 |
| المجموعة: |
LCC:Anesthesiology |
| مصطلحات موضوعية: |
Anesthetics, Feeding behavior, Neuropeptide Y, Pro-opiomelanocortin, Arcuate nucleus, Anesthesiology, RD78.3-87.3 |
| الوصف: |
Abstract Background Several hypnotic drugs have been previously identified as modulators of food intake, but exact mechanisms remain unknown. Feeding behavior implicates several neuronal populations in the hypothalamic arcuate nucleus including orexigenic neuropeptide Y and anorexigenic pro-opiomelanocortin producing neurons. The aim of this study was to investigate in mice the impact of different hypnotic drugs on food consumption and neuropeptide Y or pro-opiomelanocortine mRNA expression level in the hypothalamic arcuate nucleus. Methods Saline control, isoflurane, thiopental, midazolam or propofol were administered to C57Bl/6 mice. Feeding behavior was evaluated during 6 h. In situ hybridization of neuropeptide Y and pro-opiomelanocortine mRNAs in the hypothalamus brain region was also performed. Data were analyzed by Kruskal Wallis test and analysis of variance (p |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
1471-2253 |
| Relation: |
http://link.springer.com/article/10.1186/s12871-018-0557-x; https://doaj.org/toc/1471-2253 |
| DOI: |
10.1186/s12871-018-0557-x |
| URL الوصول: |
https://doaj.org/article/04913b7a571b4ef79003b775bf49b7e0 |
| رقم الانضمام: |
edsdoj.04913b7a571b4ef79003b775bf49b7e0 |
| قاعدة البيانات: |
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