Academic Journal

Dual Spinneret Electrospun Polyurethane/PVA-Gelatin Nanofibrous Scaffolds Containing Cinnamon Essential Oil and Nanoceria for Chronic Diabetic Wound Healing: Preparation, Physicochemical Characterization and In-Vitro Evaluation

التفاصيل البيبلوغرافية
العنوان: Dual Spinneret Electrospun Polyurethane/PVA-Gelatin Nanofibrous Scaffolds Containing Cinnamon Essential Oil and Nanoceria for Chronic Diabetic Wound Healing: Preparation, Physicochemical Characterization and In-Vitro Evaluation
المؤلفون: Mohamed Ahmed Mohamady Hussein, Oguzhan Gunduz, Ali Sahin, Mariusz Grinholc, Ibrahim Mohamed El-Sherbiny, Mosaad Megahed
المصدر: Molecules, Vol 27, Iss 7, p 2146 (2022)
بيانات النشر: MDPI AG, 2022.
سنة النشر: 2022
المجموعة: LCC:Organic chemistry
مصطلحات موضوعية: nanoceria, dual spinneret electrospinning, PU/PVA-gelatin-based nanofibrous scaffolds, diabetic wound healing, Organic chemistry, QD241-441
الوصف: In this study, a dual spinneret electrospinning technique was applied to fabricate a series of polyurethane (PU) and polyvinyl alcohol–gelatin (PVA/Gel) nanofibrous scaffolds. The study aims to enhance the properties of PU/PVA-Gel NFs loaded with a low dose of nanoceria through the incorporation of cinnamon essential oil (CEO). The as-prepared nCeO2 were embedded into the PVA/Gel nanofibrous layer, where the cinnamon essential oil (CEO) was incorporated into the PU nanofibrous layer. The morphology, thermal stability, mechanical properties, and chemical composition of the produced NF mats were investigated by STEM, DSC, and FTIR. The obtained results showed improvement in the mechanical, and thermal stability of the dual-fiber scaffolds by adding CEO along with nanoceria. The cytotoxicity evaluation revealed that the incorporation of CEO to PU/PVA-Gel loaded with a low dose of nanoceria could enhance the cell population compared to using pure PU/PVA-Gel NFs. Moreover, the presence of CEO could inhibit the growth rate of S. aureus more than E. coli. To our knowledge, this is the first time such nanofibrous membranes composed of PU and PVA-Gel have been produced. The first time was to load the nanofibrous membranes with both CEO and nCeO2. The obtained results indicate that the proposed PU/PVA-Gel NFs represent promising platforms with CEO and nCeO2 for effectively managing diabetic wounds.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1420-3049
Relation: https://www.mdpi.com/1420-3049/27/7/2146; https://doaj.org/toc/1420-3049
DOI: 10.3390/molecules27072146
URL الوصول: https://doaj.org/article/e02ebbb57f6c487fabfceda7c39861dc
رقم الانضمام: edsdoj.02ebbb57f6c487fabfceda7c39861dc
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:14203049
DOI:10.3390/molecules27072146