Academic Journal

The Human Papillomavirus E6 PDZ Binding Motif: From Life Cycle to Malignancy

التفاصيل البيبلوغرافية
العنوان: The Human Papillomavirus E6 PDZ Binding Motif: From Life Cycle to Malignancy
المؤلفون: Ketaki Ganti, Justyna Broniarczyk, Wiem Manoubi, Paola Massimi, Suruchi Mittal, David Pim, Anita Szalmas, Jayashree Thatte, Miranda Thomas, Vjekoslav Tomaić, Lawrence Banks
المصدر: Viruses, Vol 7, Iss 7, Pp 3530-3551 (2015)
بيانات النشر: MDPI AG, 2015.
سنة النشر: 2015
المجموعة: LCC:Microbiology
مصطلحات موضوعية: HPV, E6, PDZ, 14-3-3, cell polarity, Microbiology, QR1-502
الوصف: Cancer-causing HPV E6 oncoproteins are characterized by the presence of a PDZ binding motif (PBM) at their extreme carboxy terminus. It was long thought that this region of E6 had a sole function to confer interaction with a defined set of cellular substrates. However, more recent studies have shown that the E6 PBM has a complex pattern of regulation, whereby phosphorylation within the PBM can regulate interaction with two classes of cellular proteins: those containing PDZ domains and the members of the 14-3-3 family of proteins. In this review, we explore the roles that the PBM and its ligands play in the virus life cycle, and subsequently how these can inadvertently contribute towards the development of malignancy. We also explore how subtle alterations in cellular signal transduction pathways might result in aberrant E6 phosphorylation, which in turn might contribute towards disease progression.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1999-4915
97401366
Relation: http://www.mdpi.com/1999-4915/7/7/2785; https://doaj.org/toc/1999-4915
DOI: 10.3390/v7072785
URL الوصول: https://doaj.org/article/028d97401366449fb303d6059bd08eff
رقم الانضمام: edsdoj.028d97401366449fb303d6059bd08eff
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:19994915
97401366
DOI:10.3390/v7072785