Academic Journal
Tau causes synapse loss without disrupting calcium homeostasis in the rTg4510 model of tauopathy.
| العنوان: | Tau causes synapse loss without disrupting calcium homeostasis in the rTg4510 model of tauopathy. |
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| المؤلفون: | Katherine J Kopeikina, Susanne Wegmann, Rose Pitstick, George A Carlson, Brian J Bacskai, Rebecca A Betensky, Bradley T Hyman, Tara L Spires-Jones |
| المصدر: | PLoS ONE, Vol 8, Iss 11, p e80834 (2013) |
| بيانات النشر: | Public Library of Science (PLoS), 2013. |
| سنة النشر: | 2013 |
| المجموعة: | LCC:Medicine LCC:Science |
| مصطلحات موضوعية: | Medicine, Science |
| الوصف: | Neurofibrillary tangles (NFTs) of tau are one of the defining hallmarks of Alzheimer's disease (AD), and are closely associated with neuronal degeneration. Although it has been suggested that calcium dysregulation is important to AD pathogenesis, few studies have probed the link between calcium homeostasis, synapse loss and pathological changes in tau. Here we test the hypothesis that pathological changes in tau are associated with changes in calcium by utilizing in vivo calcium imaging in adult rTg4510 mice that exhibit severe tau pathology due to over-expression of human mutant P301L tau. We observe prominent dendritic spine loss without disruptions in calcium homeostasis, indicating that tangles do not disrupt this fundamental feature of neuronal health, and that tau likely induces spine loss in a calcium-independent manner. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1932-6203 |
| Relation: | https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24278327/pdf/?tool=EBI; https://doaj.org/toc/1932-6203 |
| DOI: | 10.1371/journal.pone.0080834 |
| URL الوصول: | https://doaj.org/article/020431432a1f4c968396a817fd88776f |
| رقم الانضمام: | edsdoj.020431432a1f4c968396a817fd88776f |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 19326203 |
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| DOI: | 10.1371/journal.pone.0080834 |