Academic Journal
Treatment of human papillomavirus infection in HIV-infected patients
| العنوان: | Treatment of human papillomavirus infection in HIV-infected patients |
|---|---|
| المؤلفون: | V. S. Smirnov, T. A. Kudryavtseva |
| المصدر: | Инфекция и иммунитет, Vol 11, Iss 1, Pp 79-84 (2021) |
| بيانات النشر: | NIIÈM imeni Pastera, 2021. Sankt-Peterburg , 2021. |
| سنة النشر: | 2021 |
| المجموعة: | LCC:Infectious and parasitic diseases |
| مصطلحات موضوعية: | hiv infection, human papillomavirus (hpv), hpv clinical manifestations, treatment methods, imiquimod, aldara, vartocid, immunomodulation therapy, Infectious and parasitic diseases, RC109-216 |
| الوصف: | The first reports about HIV (human immunodeficiency virus) were appeared to the 1980s. By 2017 more than 37 million people were living with HIV. Human papilloma virus (HPV) is universally spread, with some estimates showing that about 1% of the sexually active population having genital warts. Human papilloma virus (HPV)-induced infection frequently accompanies the clinical course of HIV and can manifest itself in a full spectrum of clinical-pathologic forms ranging from common warts to malignant neoplasia. Due to the widespread use of antiretroviral therapy, the number of patients with a combined infection (HIV+HPV) is steadily increasing. Here we review current clinical treatment options for HPV manifestations. High-dose antiretroviral therapy does not impede HPV treatment, and can even improve its efficacy in some cases. The topical administration of imiquimod, an immune response modifier, is an effective conservative treatment in HIV-infected patients with HPV. The immunomodulation therapy of imiquimod can serve as an effective alternative of aggressive chemical and mechanical procedures. Maximum efficacy with the lowest replaces rates may be expected from combined use of mechanical ablation methods with a subsequent follow up treatment with imiqui-mod. The best therapeutic result is expected in HIV-positive patients who are received high-dose antiretroviral treatment. The advantages of Vartocid, the modified Russian equivalent of the generic imiquimod. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | Russian |
| تدمد: | 2220-7619 2313-7398 |
| Relation: | https://www.iimmun.ru/iimm/article/view/1233; https://doaj.org/toc/2220-7619; https://doaj.org/toc/2313-7398 |
| DOI: | 10.15789/2220-7619-TOH-1233 |
| URL الوصول: | https://doaj.org/article/01e46969b978452c853cbace7062fc58 |
| رقم الانضمام: | edsdoj.01e46969b978452c853cbace7062fc58 |
| قاعدة البيانات: | Directory of Open Access Journals |
| تدمد: | 22207619 23137398 |
|---|---|
| DOI: | 10.15789/2220-7619-TOH-1233 |