Academic Journal
Immunohaematological reference values for HIV-negative healthy adults in Botswana
| العنوان: | Immunohaematological reference values for HIV-negative healthy adults in Botswana |
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| المؤلفون: | Madisa Mine, Sikhulile Moyo, Penny Stevens, Kurt Michael, Vladimir Novitsky, Kgomotso Makhaola, Aida Asmelash, S’khatele Molefhabangwe, Elias Woldegabriel, Gaseboloke Mothowaeng, Talkmore Maruta, Charity Kamhukamwe, Phibeon M. Mangwendeza, Molly Holmes-Pretorius, Isaac Mtoni, Modisa Motswaledi, Rosemary Musonda, Ndwapi Ndwapi, Joseph Makhema, Richard Marlink, Khumo Seipone, Tendani Gaolathe, Max Essex |
| المصدر: | African Journal of Laboratory Medicine, Vol 1, Iss 1, Pp e1-e7 (2011) |
| بيانات النشر: | AOSIS, 2011. |
| سنة النشر: | 2011 |
| المجموعة: | LCC:Public aspects of medicine LCC:Medicine (General) |
| مصطلحات موضوعية: | Botswana, HIV-negative, Immunohaematology, reference intervals, T-lymphocytes, Public aspects of medicine, RA1-1270, Medicine (General), R5-920 |
| الوصف: | Background: Clinical laboratories in Botswana have relied entirely on the reference intervals for normal immunohaematological values provided by manufacturers’ kits and textbooks. Objectives: The aim of this study was to determine the means, medians, 2.5th and 97.5th percentile reference intervals, for normal immunohaematological values in healthy adults in Botswana. Method: A total of 261 healthy participants comprising 126 men (48%) and 135 (52%) women were enrolled in the southern part of Botswana, and immunological and haematological laboratory parameters were measured. Results: The mean age was 28.8 (95% Confidence Interval [CI] 27.7–29.8) years, with a median of 27 years and a range 18–66 years. The mean haemoglobin level was significantly lower for women (12.4 g/dL; 95% CI 12.1% – 12.7%) than men (15.1 g/dL; 95% CI 14.9% – 15.3%). The women’s haemoglobin reference values (9.0 g/dL – 15.0 g/dL) levels were lower than observed in predominantly White populations (12.0 g/dL – 16.0 g/dL), but comparable with regional consensus reference intervals (9.5 g/dL – 15.8 g/dL) recently defined for East and Southern Africa. Conclusion: The established values provide an important tool for patient management and could influence decisions on inclusion of participants and adverse events in clinical trials conducted locally. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2225-2002 2225-2010 |
| Relation: | https://ajlmonline.org/index.php/ajlm/article/view/5; https://doaj.org/toc/2225-2002; https://doaj.org/toc/2225-2010 |
| DOI: | 10.4102/ajlm.v1i1.5 |
| URL الوصول: | https://doaj.org/article/d01b150442da4422947a844a315796d2 |
| رقم الانضمام: | edsdoj.01b150442da4422947a844a315796d2 |
| قاعدة البيانات: | Directory of Open Access Journals |
| تدمد: | 22252002 22252010 |
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| DOI: | 10.4102/ajlm.v1i1.5 |