Academic Journal
Diagnostic value of hybrid perfusion SPECT/CT and CTPA for detection of pulmonary embolism
| العنوان: | Diagnostic value of hybrid perfusion SPECT/CT and CTPA for detection of pulmonary embolism |
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| المؤلفون: | Sevda Naydenska, Konstantin Grudkov, Daniela Petrova, Dora Zlatareva, Bilyukov Radoslav, Daniela Krasimirova, Ventsislava Pencheva |
| المصدر: | Biotechnology & Biotechnological Equipment, Vol 37, Iss 1, Pp 34-41 (2023) |
| بيانات النشر: | Taylor & Francis Group, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Biotechnology |
| مصطلحات موضوعية: | Pulmonary embolism, diagnosis, perfusion SPECT/CT, SPECT–low dose CT, CTPA, Biotechnology, TP248.13-248.65 |
| الوصف: | The diagnosis of pulmonary embolism (PE) employs a combination of clinical assessment, D-dimer assay and imaging with pulmonary ventilation-perfusion (V/P) scintigraphy and/or computed tomography pulmonary angiography (CTPA). It is generally accepted that V/P SPECT and CTPA have high diagnostic accuracy. Nonetheless, there are only limited data directly comparing these two modalities. This prospective cross-sectional study included 184 hospitalized patients with clinically suspected PE. Clinical assessment, electrocardiography (ECG), vein ultrasound, echocardiography, arterial blood gas test, D-dimer assay, perfusion single photon-emission computed tomography/computed tomography (P-SPECT/CT) and CTPA were carried out. PE was diagnosed in 109 of 146 patients (74.66%) by P-SPECT/CT and 47 of 89 patients (52.81%) by CTPA. The sensitivity and specificity of P-SPECT/CT were 82.9%, respectively, 64.7%. The positive predictive value of SPECT/CT was 94.7%, the negative predictive value was 33.3% and the validity was 80.8%. For CTPA the sensitivity was 58.2% and specificity 90%. The positive predictive value of CTPA was 97.9%, the negative predictive value 21.4% and the accuracy (performance) 61.8%. There was no significant difference between the two methods regarding the diagnosis of PE at sub-segmental and segmental level. The sensitivity of P-SPECT/CT was significantly higher compared with CTPA, whereas the specificity was significantly higher at CTPA for diagnosis of PE. The P-SPECT/CT showed excellent diagnostic performance with high sensitivity and a very high positive predictive value. Thus, it could serve as first-line imaging for PE in the number of prevalent cases. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 13102818 1314-3530 1310-2818 |
| Relation: | https://doaj.org/toc/1310-2818; https://doaj.org/toc/1314-3530 |
| DOI: | 10.1080/13102818.2022.2153081 |
| URL الوصول: | https://doaj.org/article/019cdb2f914e49bb8364ddc5ef3fd092 |
| رقم الانضمام: | edsdoj.019cdb2f914e49bb8364ddc5ef3fd092 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 13102818 13143530 |
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| DOI: | 10.1080/13102818.2022.2153081 |