Academic Journal
Investigating the impact of clinical and genetic factors on the post-surgery prognosis of sinonasal squamous cell carcinoma
| العنوان: | Investigating the impact of clinical and genetic factors on the post-surgery prognosis of sinonasal squamous cell carcinoma |
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| المؤلفون: | Meng Lian, Boxuan Han, Jiaming Chen, Xixi Shen, Yanming Zhao, Qian Shi, Ling Feng, Shizhi He, Hongzhi Ma, Lizhen Hou, Qi Zhong, Hongbao Cao, Jugao Fang |
| المصدر: | Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024) |
| بيانات النشر: | Nature Portfolio, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Medicine LCC:Science |
| مصطلحات موضوعية: | SNSCC, Overall survival, Recurrence-free survival, Genetic factor, Prognosis analysis, Medicine, Science |
| الوصف: | Abstract Sinonasal squamous cell carcinoma (SNSCC) is an aggressive cancer affecting the nasal and sinus regions, with its progression factors, particularly genetic ones, not yet fully understood. Here, we first conducted a retrospective study with 219 SNSCC patients to identify clinical factors affecting SNSCC prognosis. Additionally, we mined a vast literature dataset to uncover genetic factors associated with SNSCC progression. Based on this data, we constructed SNSCC prognosis pathways and performed a gene set enrichment analysis (GSEA). Clear operative margins were linked to a 73.5–86.3% improvement in overall survival and a 73.5–88.9% lower risk of recurrence. Nasal cavity-originated cases exhibited a 67.6–97.4% decrease in mortality and an 80.7–96.7% lower recurrence rate. Patients at T1-2 staging had a 65.0–80.6% reduced risk of death and recurrence compared to those at T3 stage. Additionally, we identified 53 genes associated with SNSCC, with 14 also implicated in primary tumor site, T stage, and operative margin. These genes, including EGFR, PIK3CA, ERBB2, PTEN, BCL2, BRAF, KRAS, and PRL, form a complex SNSCC-prognosis pathway and were significantly enriched in 42 KEGG pathways and Gene Ontology (GO) terms (FDR-corrected p-value |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2045-2322 |
| Relation: | https://doaj.org/toc/2045-2322 |
| DOI: | 10.1038/s41598-024-73157-6 |
| URL الوصول: | https://doaj.org/article/013f67d26ba64cd483dd29a0fa236d25 |
| رقم الانضمام: | edsdoj.013f67d26ba64cd483dd29a0fa236d25 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 20452322 |
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| DOI: | 10.1038/s41598-024-73157-6 |