التفاصيل البيبلوغرافية
| العنوان: |
A noncanonical AR addiction drives enzalutamide resistance in prostate cancer |
| المؤلفون: |
Yundong He, Ting Wei, Zhenqing Ye, Jacob J. Orme, Dong Lin, Haoyue Sheng, Ladan Fazli, R. Jeffrey Karnes, Rafael Jimenez, Liguo Wang, Liewei Wang, Martin E. Gleave, Yuzhuo Wang, Lei Shi, Haojie Huang |
| المصدر: |
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021) |
| بيانات النشر: |
Nature Portfolio, 2021. |
| سنة النشر: |
2021 |
| المجموعة: |
LCC:Science |
| مصطلحات موضوعية: |
Science |
| الوصف: |
Resistance to second generation anti-androgen therapies such as enzalutamide (ENZ) can emerge in prostate cancer patients. Here, the authors identify an ENZ-resistant mechanism driven by AR-dependent transcription of noncanonical targets that make resistant cells susceptible to dual inhibition of BET and CBP/p300 signaling. |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
2041-1723 |
| Relation: |
https://doaj.org/toc/2041-1723 |
| DOI: |
10.1038/s41467-021-21860-7 |
| URL الوصول: |
https://doaj.org/article/00b4af7118804738bdce75145ea247c5 |
| رقم الانضمام: |
edsdoj.00b4af7118804738bdce75145ea247c5 |
| قاعدة البيانات: |
Directory of Open Access Journals |
Full Text Finder