Dissertation/ Thesis
The Suppressive Effect of Acute Phase Response on Hepatic Cytochrome P450-Dependent Drug Metabolism in Dogs and Rabbits
| العنوان: | The Suppressive Effect of Acute Phase Response on Hepatic Cytochrome P450-Dependent Drug Metabolism in Dogs and Rabbits イヌおよびウサギにおける肝チトクロームP450依存薬物代謝に対する急性相反応の抑制効果 |
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| المؤلفون: | 齋藤, 敏樹, Toshiki Saitoh [著] |
| بيانات النشر: | [Toshiki Saitoh], 2000. |
| سنة النشر: | 2000 |
| وصف مادي: | 1冊 |
| Contents Note: | Contents / (0003.jp2) -- Chapter 1 Introduction / p1 (0005.jp2) -- 1.1 Acute phase response(APR) / p2 (0006.jp2) -- 1.2 Cytochrome P450(CYP) / p3 (0007.jp2) -- 1.3 Purpose / p5 (0009.jp2) -- Table 1-1.Compounds and reactions claimed to demonstrate a high degree of human CYP specificity / p7 (0011.jp2) -- Table 1-2.Probe substances claimed to be useful in human / p8 (0012.jp2) -- Chapter 2 The suppressive effects of lipopolysaccharide-induced acute phase response on hepatic cytochrome P450-dependent drug metabolism in rabbits / p9 (0013.jp2) -- 2.1 Objective / p10 (0014.jp2) -- 2.2 Materials and methods / p10 (0014.jp2) -- 2.3 Results / p19 (0023.jp2) -- 2.4 Discussion / p22 (0026.jp2) -- 2.5 Conclusion / p24 (0028.jp2) -- Table 2-1.Rectal body temperatures(℃)in control and LPS-treated rabbits / p25 (0029.jp2) -- Table 2-2.Plasma concentration of CRP(mg/dL)in control and LPS-treated rabbits / p26 (0030.jp2) -- Table 2-3.Plasma concentration of ALB(g/dL)in control and LPS-treated rabbits / p27 (0031.jp2) -- Table 2-4.Pharmacokinetic parameters of antipyrine in control and LPS-treated rabbits / p28 (0032.jp2) -- Table 2-5.Effect of APR on CYP enzymes and UDP-glucuronosyl transferase / p29 (0033.jp2) -- Table 2-6.Vmax and Km values of the CYP enzymes in group I / p30 (0034.jp2) -- Fig.2-1.Plasma concentration of IL-6 / p31 (0035.jp2) -- Fig.2-2.Plasma antipyrine time-concentration curves / p32 (0036.jp2) -- Fig.2-3.Total content of cytochrome P450 / p33 (0037.jp2) -- Fig.2-4.Western blot analysis / p34 (0038.jp2) -- Chapter 3 The impact of acute phase response on the plasma clearance of antipyrine, theophylline,phenytoin and nifedipine in rabbits / p35 (0039.jp2) -- 3.1 Objective / p36 (0040.jp2) -- 3.2 Materials and methods / p36 (0040.jp2) -- 3.3 Results / p41 (0045.jp2) -- 3.4 Discussion / p43 (0047.jp2) -- 3.5 Conclusion / p45 (0049.jp2) -- Table 3-1.Pharmacokinetic parameters of antipyrine,theophylline,phenytoin and nifedipine in control and LPS-treated rabbits / p46 (0050.jp2) -- Fig.3-1.Rectal body temperatures / p47 (0051.jp2) -- Fig.3-2.Plasma IL-6 concentrations / p48 (0052.jp2) -- Fig.3-3.Plasma time-concentration curves / p49 (0053.jp2) -- Chapter 4 The downregulation of hepatic cytochrome P450-dependent drug metabolism in dogs during acute phase response / p50 (0054.jp2) -- 4.1 Objective / p51 (0055.jp2) -- 4.2 Materials and methods / p51 (0055.jp2) -- 4.3 Results / p60 (0064.jp2) -- 4.4 Discussion / p61 (0065.jp2) -- 4.5 Conclusion / p64 (0068.jp2) -- Table 4-1.Enzyme kinetics parameters and CYP contents in control and LPS-treated dogs / p65 (0069.jp2) -- Table 4-2.Pharmacokinetic parameters of antipyrine,theophylline,phenytoin and nifedipine in control and LPS-treated dogs / p66 (0070.jp2) -- Fig.4-1.Rectal body temperatures and Plasma IL-1β concentrations / p67 (0071.jp2) -- Fig.4-2.Western blot analysis / p68 (0072.jp2) -- Chapter 5 General discussion / p69 (0073.jp2) -- 5.1 APR induction / p70 (0074.jp2) -- 5.2 CYP-dependent activity during APR / p72 (0076.jp2) -- 5.3 Pharmacokinetics of drugs during APR / p74 (0078.jp2) -- 5.4 Acute phase protein and ALB / p77 (0081.jp2) -- 5.5 Conclusion / p78 (0082.jp2) -- Acknowledgment / p80 (0084.jp2) -- References / p81 (0085.jp2) |
| نوع الوثيقة: | 博士論文 |
| اللغة: | English |
| Rights: | 国立国会図書館/図書館・個人送信限定 |
| ملاحظات: | 博士論文 |
| رقم الانضمام: | edsdlc.I002011540.00 |
| قاعدة البيانات: | National Diet Library Digital Collections - 国立国会図書館デジタルコレクション |
| الوصف غير متاح. |