Academic Journal
Polyuridylation in Eukaryotes: A 3′-End Modification Regulating RNA Life
| العنوان: | Polyuridylation in Eukaryotes: A 3′-End Modification Regulating RNA Life |
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| المؤلفون: | Paola Munoz-Tello, Lional Rajappa, Sandrine Coquille, Stéphane Thore |
| المصدر: | BioMed Research International, Vol 2015 (2015) |
| بيانات النشر: | Hindawi Limited |
| سنة النشر: | 2015 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | Medicine |
| الوصف: | In eukaryotes, mRNA polyadenylation is a well-known modification that is essential for many aspects of the protein-coding RNAs life cycle. However, modification of the 3′ terminal nucleotide within various RNA molecules is a general and conserved process that broadly modulates RNA function in all kingdoms of life. Numerous types of modifications have been characterized, which are generally specific for a given type of RNA such as the CCA addition found in tRNAs. In recent years, the addition of nontemplated uridine nucleotides or uridylation has been shown to occur in various types of RNA molecules and in various cellular compartments with significantly different outcomes. Indeed, uridylation is able to alter RNA half-life both in positive and in negative ways, highlighting the importance of the enzymes in charge of performing this modification. The present review aims at summarizing the current knowledge on the various processes leading to RNA 3′-end uridylation and on their potential impacts in various diseases. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| ردمك: | 978-5-09-543755-9 5-09-543755-4 |
| تدمد: | 2314-6133 2314-6141 |
| Relation: | http://dx.doi.org/10.1155/2015/968127; https://doaj.org/toc/2314-6133; https://doaj.org/toc/2314-6141; https://doaj.org/article/bcc509543755464abb84f48a4d65a32b |
| DOI: | 10.1155/2015/968127 |
| الاتاحة: | https://doi.org/10.1155/2015/968127 https://doaj.org/article/bcc509543755464abb84f48a4d65a32b |
| رقم الانضمام: | edsbas.FFD63AE1 |
| قاعدة البيانات: | BASE |
Full Text Finder | ردمك: | 9785095437559 5095437554 |
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| تدمد: | 23146133 23146141 |
| DOI: | 10.1155/2015/968127 |