Academic Journal
Interleukin-6 in Rheumatoid Arthritis
| العنوان: | Interleukin-6 in Rheumatoid Arthritis |
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| المؤلفون: | Pandolfi, Franco, Franza, Laura, Andriollo, Gloria, Nucera, Eleonora |
| المساهمون: | Pandolfi, Franco, Franza, Laura, Carusi, Valentina, Altamura, Simona, Andriollo, Gloria, Nucera, Eleonora |
| بيانات النشر: | MDPI |
| سنة النشر: | 2020 |
| المجموعة: | Università Cattolica del Sacro Cuore: PubliCatt |
| مصطلحات موضوعية: | IL-6, inflammation, rheumatoid arthritis, Antibodies, Monoclonal, Arthritis, Rheumatoid, Disease Progression, Humans, Interleukin-6, Molecular Targeted Therapy, Signal Transduction, Settore MED/09 - MEDICINA INTERNA |
| الوصف: | The role of interleukin (IL)-6 in health and disease has been under a lot of scrutiny in recent years, particularly during the recent COVID-19 pandemic. The inflammatory pathways in which IL-6 is involved are also partly responsible of the development and progression of rheumatoid arthritis (RA), opening interesting perspectives in terms of therapy. Anti-IL-6 drugs are being used with variable degrees of success in other diseases and are being tested in RA. Results have been encouraging, particularly when anti-IL-6 has been used with other drugs, such as metothrexate (MTX). In this review we discuss the main immunologic aspects that make anti-IL-6 a good candidate in RA, but despite the main therapeutic options available to target IL-6, no gold standard treatment has been established so far. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/32718086; info:eu-repo/semantics/altIdentifier/wos/WOS:000567289500001; volume:21; issue:15; firstpage:5238; lastpage:N/A; issueyear:2020; journal:INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES; http://hdl.handle.net/10807/161301 |
| DOI: | 10.3390/ijms21155238 |
| الاتاحة: | http://hdl.handle.net/10807/161301 https://doi.org/10.3390/ijms21155238 |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.FFB305CE |
| قاعدة البيانات: | BASE |
| DOI: | 10.3390/ijms21155238 |
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