Academic Journal
Integrated F-Fluorodeoxyglucose–Positron Emission Tomography/Dynamic Contrast-Enhanced Computed Tomography to Phenotype Non–Small Cell Lung Carcinoma
| العنوان: | Integrated F-Fluorodeoxyglucose–Positron Emission Tomography/Dynamic Contrast-Enhanced Computed Tomography to Phenotype Non–Small Cell Lung Carcinoma |
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| المؤلفون: | Manu Shastry, Kenneth A. Miles, Thida Win, Sam M. Janes, Raymond Endozo, Marie Meagher, Peter J. Ell, Ashley M. Groves |
| المصدر: | Molecular Imaging, Vol 11 (2012) |
| بيانات النشر: | SAGE Publications |
| سنة النشر: | 2012 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | Biology (General), QH301-705.5, Medical technology, R855-855.5 |
| الوصف: | We applied modern molecular and functional imaging to the pretreatment assessment of lung cancer using combined dynamic contrast-enhanced computed tomography (DCE-CT) and 18 F-fluorodeoxyglucose–positron emission tomography ( 18 F-FDG-PET) to phenotype tumors. Seventy-four lung cancer patients were prospectively recruited for 18 F-FDG-PET/DCE-CT using PET/64-detector CT. After technical failures, there were 64 patients (35 males, 29 females; mean age [± SD] 67.5 ± 7.9 years). DCE-CT yielded tumor peak enhancement (PE) and standardized perfusion value (SPV). The uptake of 18 F-FDG quantified on PET as the standardized uptake value (SUV max ) assessed tumor metabolism. The median values for SUV max and SPV were used to define four vascular-metabolic phenotypes. There were associations (Spearman rank correlation [ rs ]) between tumor size and vascular-metabolic parameters: SUV max versus size ( rs = .40, p = .001) and SUV/PE versus size ( r = .43, p < .001). Patients with earlier-stage (1-HA, n = 30) disease had mean (± SD) SUV/PE 0.36 ± 0.28 versus 0.56 ± 0.32 in later-stage (stage IIB-IV, n = 34) disease ( p = .007). The low metabolism with high vascularity phenotype was significantly more common among adenocarcinomas ( p = .018), whereas the high metabolism with high vascularity phenotype was more common among squamous cell carcinomas ( p = .024). Other non-small cell lung carcinoma tumor types demonstrated a high prevalence of the high metabolism with low vascularity phenotype ( p = .028). We show that tumor subtypes have different vascular-metabolic associations, which can be helpful clinically in managing lung cancer patients to hone targeted therapy. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1536-0121 |
| Relation: | https://doi.org/10.2310/7290.2011.00052; https://doaj.org/toc/1536-0121; https://doaj.org/article/ca294ed80b2347f08c55e2306e8206a9 |
| DOI: | 10.2310/7290.2011.00052 |
| الاتاحة: | https://doi.org/10.2310/7290.2011.00052 https://doaj.org/article/ca294ed80b2347f08c55e2306e8206a9 |
| رقم الانضمام: | edsbas.FFAAF73F |
| قاعدة البيانات: | BASE |
| تدمد: | 15360121 |
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| DOI: | 10.2310/7290.2011.00052 |