Academic Journal
Meriva®, a lecithinized curcumin delivery system, in diabetic microangiopathy and retinopathy
| العنوان: | Meriva®, a lecithinized curcumin delivery system, in diabetic microangiopathy and retinopathy |
|---|---|
| المؤلفون: | R. Steigerwalt, NEBBIOSO, Marcella, G. Appendino, G. Belcaro, G. Ciammaichella, U. Cornelli, R. Luzzi, S. Togni, M. Dugall, M. R. Cesarone, E. Ippolito, B. M. Errichi, A. Ledda, M. Hosoi, M. Corsi |
| المساهمون: | R., Steigerwalt, Nebbioso, Marcella, G., Appendino, G., Belcaro, G., Ciammaichella, U., Cornelli, R., Luzzi, S., Togni, M., Dugall, M. R., Cesarone, E., Ippolito, B. M., Errichi, A., Ledda, M., Hosoi, M., Corsi |
| بيانات النشر: | Edizioni Minerva Medica Torino |
| سنة النشر: | 2012 |
| المجموعة: | Sapienza Università di Roma: CINECA IRIS |
| مصطلحات موضوعية: | meriva®, curcumin, diabetic microangiopathy, diabete, retinal microangiopathy, microcirculation, laser doppler, oedema |
| الوصف: | In the present study, the improvement of diabetic microangiopathy and retinopathy was evaluated in 38 diabetic patients treated with a novel curcumin phospholipids delivery form (Meriva®). Diabetes was diagnosed at least 5 years before inclusion and all patients had signs of retinal oedema and of peripheral microangiopathy. Meriva® was administered at the dosage of 2 tablets/day (each tablet containing 500 mg Meriva® corresponding to 100 mg curcumin) for a period of at least 4 weeks in addition to the standard management plan, while a comparable group of subjects (n = 39) followed the standard management plan alone. All subjects (treatment and controls) completed the follow-up period, there were no dropouts and Meriva® showed an optimal tolerability. At 4 weeks, microcirculatory and clinical evaluations indicated an improvement of microangiopathy. In terms of peripheral microangiopathy, in the Meriva® group, there was a significant improvement in the venoarteriolar response (p<0.05) and a decrease in the score of peripheral oedema (p<0.05), a sign typically associated with the failure of the venoarteriolar response. At the retinal level, high-resolution, duplex scanning, used to measure retinal flow, showed improvements in the Meriva® treated patients. The evaluation of retinal oedema (Steigerwalt's scale) showed an improvement associated with improved visual acuity (Snellen scale). There were no clinical or microcirculatory effects in controls. These preliminary observations, indicate the value of curcumin, when administered in a bioavailable form as with Meriva®, in the management of diabetic microangiopathy and retinopathy. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | STAMPA |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/23241930; info:eu-repo/semantics/altIdentifier/wos/WOS:000209802000003; volume:54; issue:1 Suppl 4; firstpage:11; lastpage:16; numberofpages:6; journal:PANMINERVA MEDICA; http://hdl.handle.net/11573/505004; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84876532915; http://www.minervamedica.it/en/search.php |
| الاتاحة: | http://hdl.handle.net/11573/505004 http://www.minervamedica.it/en/search.php |
| Rights: | info:eu-repo/semantics/closedAccess |
| رقم الانضمام: | edsbas.FF748197 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |