Academic Journal
Lithium response in bipolar disorder is associated with focal adhesion and PI3K-Akt networks: a multi-omics replication study
| العنوان: | Lithium response in bipolar disorder is associated with focal adhesion and PI3K-Akt networks: a multi-omics replication study |
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| المؤلفون: | Ou, Anna H., Rosenthal, Sara B., Adli, Mazda, Akiyama, Kazufumi, Akula, Nirmala, Alda, Martin, Amare, Azmeraw T., Ardau, Raffaella, Arias, Bárbara, Aubry, Jean-Michel, Kelsoe, John R. |
| المساهمون: | Ou, Anna H., Rosenthal, Sara B., Adli, Mazda, Akiyama, Kazufumi, Akula, Nirmala, Alda, Martin, Amare, Azmeraw T., Ardau, Raffaella, Arias, Bárbara, Aubry, Jean-Michel, Kelsoe, John R. |
| سنة النشر: | 2024 |
| المجموعة: | Georg-August-Universität Göttingen: GoeScholar |
| الوصف: | Lithium is the gold standard treatment for bipolar disorder (BD). However, its mechanism of action is incompletely understood, and prediction of treatment outcomes is limited. In our previous multi-omics study of the Pharmacogenomics of Bipolar Disorder (PGBD) sample combining transcriptomic and genomic data, we found that focal adhesion, the extracellular matrix (ECM), and PI3K-Akt signaling networks were associated with response to lithium. In this study, we replicated the results of our previous study using network propagation methods in a genome-wide association study of an independent sample of 2039 patients from the International Consortium on Lithium Genetics (ConLiGen) study. We identified functional enrichment in focal adhesion and PI3K-Akt pathways, but we did not find an association with the ECM pathway. Our results suggest that deficits in the neuronal growth cone and PI3K-Akt signaling, but not in ECM proteins, may influence response to lithium in BD. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | https://resolver.sub.uni-goettingen.de/purl?gro-2/141906; 2811 |
| DOI: | 10.1038/s41398-024-02811-4 |
| الاتاحة: | https://resolver.sub.uni-goettingen.de/purl?gro-2/141906 https://doi.org/10.1038/s41398-024-02811-4 |
| Rights: | info:eu-repo/semantics/openAccess ; https://creativecommons.org/licenses/by/4.0 |
| رقم الانضمام: | edsbas.FF5C899A |
| قاعدة البيانات: | BASE |
| DOI: | 10.1038/s41398-024-02811-4 |
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