التفاصيل البيبلوغرافية
| العنوان: |
Discovery of Natural Dimeric Naphthopyrones as Potential Cytotoxic Agents through ROS-Mediated Apoptotic Pathway |
| المؤلفون: |
Kuo Xu, Chuanlong Guo, Jie Meng, Haiying Tian, Shuju Guo, Dayong Shi |
| المصدر: |
Marine Drugs; Volume 17; Issue 4; Pages: 207 |
| بيانات النشر: |
Multidisciplinary Digital Publishing Institute |
| سنة النشر: |
2019 |
| المجموعة: |
MDPI Open Access Publishing |
| مصطلحات موضوعية: |
Aspergillus, naphthopyrones, cytotoxicity, endophytic fungus, Leathesia nana |
| جغرافية الموضوع: |
agris |
| الوصف: |
A study on the secondary metabolites of Aspergillus sp. XNM-4, which was derived from marine algae Leathesia nana (Chordariaceae), led to the identification of one previously undescribed (1) and seventeen known compounds (2–18). Their planar structures were established by extensive spectroscopic analyses, while the stereochemical assignments were defined by electronic circular dichroism (ECD) calculations. The biological activities of the compounds were assessed on five human cancer cell lines (PANC-1, A549, MDA-MB-231, Caco-2, and SK-OV-3), and one human normal cell line (HL-7702) using an MTT [3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl tetrazolium bromide] assay. Among them, the dimeric naphthopyrones 7, 10 and 12 exhibited potent cytotoxicity. Further mechanism studies showed that 12 induced apoptosis, arrested the cell cycle at the G0/G1 phase in the PANC-1 cells, caused morphological changes and generated ROS; and it induces PANC-1 cells apoptosis via ROS-mediated PI3K/Akt signaling pathway. |
| نوع الوثيقة: |
text |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| Relation: |
Marine Pharmacology; https://dx.doi.org/10.3390/md17040207 |
| DOI: |
10.3390/md17040207 |
| الاتاحة: |
https://doi.org/10.3390/md17040207 |
| Rights: |
https://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: |
edsbas.FF1A8027 |
| قاعدة البيانات: |
BASE |