Academic Journal
Polymorphisms in the CTLA4 promoter sequence are associated with canine hypoadrenocorticism
| العنوان: | Polymorphisms in the CTLA4 promoter sequence are associated with canine hypoadrenocorticism |
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| المؤلفون: | Boag, A M, Short, A, Kennedy, L J, Syme, H, Graham, P A, Catchpole, B |
| سنة النشر: | 2020 |
| المجموعة: | RVC Research Online (Royal Veterinary College, University of London) |
| الوصف: | Canine hypoadrenocorticism is an immune-mediated endocrinopathy that shares both clinical and pathophysiological similarities with Addison’s disease in humans. Several dog breeds are overrepresented in the disease population, suggesting that a genetic component is involved, although this is likely to be polygenic. Previous research has implicated CTLA4 as a potential susceptibility gene. CTLA4 is an important regulator of T cell function and polymorphisms/mutations in CTLA4 have been associated with a number of autoimmune phenotypes in both humans and rodent models of autoimmunity. The aim of the current study was to undertake a case:control association study of CTLA4 promotor polymorphisms in three dog breeds, cocker spaniels, springer spaniels and West Highland white terriers (WHWT). |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | text |
| اللغة: | English |
| Relation: | https://researchonline.rvc.ac.uk/id/eprint/12598/1/12598_Polymorphisms-in-the-CTLA4-promoter-sequence-are-associated-with-canine-hypoadrenocorticism.pdf; Boag, A M and Short, A and Kennedy, L J and Syme, H and Graham, P A and Catchpole, B (2020) Polymorphisms in the CTLA4 promoter sequence are associated with canine hypoadrenocorticism. Canine Medicine and Genetics, 7 (2). |
| DOI: | 10.1186/s40575-020-0081-4 |
| الاتاحة: | https://researchonline.rvc.ac.uk/id/eprint/12598/ https://researchonline.rvc.ac.uk/id/eprint/12598/1/12598_Polymorphisms-in-the-CTLA4-promoter-sequence-are-associated-with-canine-hypoadrenocorticism.pdf https://doi.org/10.1186/s40575-020-0081-4 |
| Rights: | cc_by_4 |
| رقم الانضمام: | edsbas.FF0EADD |
| قاعدة البيانات: | BASE |
| DOI: | 10.1186/s40575-020-0081-4 |
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