التفاصيل البيبلوغرافية
| العنوان: |
Corpora amylacea act as containers that remove waste products from the brain |
| المؤلفون: |
Riba Baqués, Marta, Augé Marí, Elisabet, Campo Sabariz, Joan, Moral Anter, David, Molina Porcel, Laura, Ximelis, Teresa, Ferrer i Roig, Ruth, Martín Venegas, Raquel, Pelegrí i Gabaldà, Carme, Vilaplana i Hortensi, Jordi |
| المصدر: |
Articles publicats en revistes (Bioquímica i Fisiologia) |
| بيانات النشر: |
National Academy of Sciences |
| سنة النشر: |
2019 |
| المجموعة: |
Dipòsit Digital de la Universitat de Barcelona |
| مصطلحات موضوعية: |
Envelliment, Malalties neurodegeneratives, Metabolisme, Immunologia, Sistema limfàtic, Sistema immunitari, Fagocitosi, Astròcits, Aging, Neurodegenerative Diseases, Metabolism, Immunology, Lymphatics, Immune system, Phagocytosis, Astrocytes |
| الوصف: |
Corpora amylacea (CA) in the human brain are granular bodies formed by polyglucosan aggregates that amass waste products of different origins. They are generated by astrocytes, mainly during aging and neurodegenerative conditions, and are located predominantly in periventricular and subpial regions. This study shows that CA are released from these regions to the cerebrospinal fluid and are present in the cervical lymph nodes, into which cerebrospinal fluid drains through the meningeal lymphatic system. We also show that CA can be phagocytosed by macrophages. We conclude that CA can act as containers that remove waste products from the brain and may be involved in a mechanism that cleans the brain. Moreover, we postulate that CA may contribute in some autoimmune brain diseases, exporting brain substances that interact with the immune system, and hypothesize that CA may contain brain markers that may aid in the diagnosis of certain brain diseases. |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
11 p.; application/pdf |
| اللغة: |
English |
| تدمد: |
0027-8424 |
| Relation: |
Versió postprint del document publicat a: https://doi.org/10.1073/pnas.1913741116; Proceedings of the National Academy of Sciences of the United States of America - PNAS, 2019, vol. 116, num. 51, p. 26038-26048; https://doi.org/10.1073/pnas.1913741116; http://hdl.handle.net/2445/162761; 693639 |
| الاتاحة: |
http://hdl.handle.net/2445/162761 |
| Rights: |
(c) Riba Baqués, Marta et al., 2019 ; info:eu-repo/semantics/openAccess |
| رقم الانضمام: |
edsbas.FF086879 |
| قاعدة البيانات: |
BASE |
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