Academic Journal
P0152 Distinct faecal metabolic profiles associated with endoscopic remission in ulcerative colitis patients following faecal microbiota transplantation
| العنوان: | P0152 Distinct faecal metabolic profiles associated with endoscopic remission in ulcerative colitis patients following faecal microbiota transplantation |
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| المؤلفون: | Jiwa, F, Jitsumara, M, Hugo, S, Takis, P, Ghiboub, M, Kinross, J, Harris, D, Hitchings, M |
| المصدر: | Journal of Crohn's and Colitis ; volume 19, issue Supplement_1, page i543-i543 ; ISSN 1873-9946 1876-4479 |
| بيانات النشر: | Oxford University Press (OUP) |
| سنة النشر: | 2025 |
| الوصف: | Background While FMT has shown promise in inducing remission in ulcerative colitis (UC) patients, there are still high rates of non-response (1). Identifying patterns associated with treatment response may help optimize FMT and improve the management of UC patients by identifying FMT's underlying mechanisms. This study aimed to examine the faecal metabolic profile of UC patients post-FMT to identify key metabolites and metabolic pathways linked to treatment response. Methods Faecal samples were collected from 18 treatment-naïve UC patients recruited from a single-centre, single-blinded randomised controlled trial (ISRCTN58082603). All patients received antibiotics and bowel lavage before randomisation into three groups: (1) a single FMT enema (n=7), (2) five consecutive FMT enemas over five days (n=7), and (3) a control group receiving only antibiotics and bowel lavage (n=4). Samples were collected at baseline (week 0) and at weeks 1, 4, 8, and 12 post-treatment. Treatment response was defined as endoscopic remission or a drop of ≥2 points in the partial Mayo score. Faecal samples were analysed using 1H-NMR spectroscopy. Univariate statistics analysis was performed on processed spectral data using Metaboanalyst 5.0. Results Among 18 patients (median age 42, range 18-70; 7 (39%) male), 3 of 14 in the FMT groups and 2 in the control group achieved endoscopic remission. Faecal metabolic profiles were available for 58 samples at week (W) 0, W4, W8 and W12, showing a total of 23 targeted metabolites. Although no individual metabolites were significantly changed across groups and all timepoints, pathway-specific analysis revealed distinct metabolic shifts in responders post-FMT. Responders showed a reduction in purine metabolism and alanine synthesis, whereas non-responders’ metabolic profile remained comparable to baseline (W0), suggesting these pathways may play a role in remission induction. Disturbances in purine metabolism have been linked to inflammatory conditions, including inflammatory bowel disease ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1093/ecco-jcc/jjae190.0326 |
| الاتاحة: | https://doi.org/10.1093/ecco-jcc/jjae190.0326 https://academic.oup.com/ecco-jcc/article-pdf/19/Supplement_1/i543/61543125/jjae190.0326.pdf |
| Rights: | https://academic.oup.com/pages/standard-publication-reuse-rights |
| رقم الانضمام: | edsbas.FEF2C980 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1093/ecco-jcc/jjae190.0326 |
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