Academic Journal
Bottom-up layer-by-layer assembling of antibacterial freestanding nanobiocomposite films
| العنوان: | Bottom-up layer-by-layer assembling of antibacterial freestanding nanobiocomposite films |
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| المؤلفون: | Francesko, Antonio, Ivanova, Kristina Dimitrova, Hoyo Pérez, Javier, Pérez-Rafael, Silvia, Petkova, Petya, Fernandes Macedo, Margarida Maria, Heinze, Thomas, Mendoza Gómez, Ernesto, Tzanov, Tzanko |
| المساهمون: | Universitat Politècnica de Catalunya. Departament d'Enginyeria Química, Universitat Politècnica de Catalunya. Departament de Física, Universitat Politècnica de Catalunya. GBMI - Grup de Biotecnologia Molecular i Industrial, Universitat Politècnica de Catalunya. GCM - Grup de Caracterització de Materials |
| سنة النشر: | 2018 |
| المجموعة: | Universitat Politècnica de Catalunya (UPC): Tesis Doctorals en Xarxa (TDX) / Theses and Dissertations Online |
| مصطلحات موضوعية: | Àrees temàtiques de la UPC::Enginyeria química, Chitosan, Biopolymers, Nanoparticles--therapeutic use, aminocellulose, hyaluronic acid, biopolyme r-capped silver 1 nanoparticles, layer-by-layer, freestanding antimicrobial films, Quitosan, Biopolímers, Nanopartícules -- Ús terapèutic |
| الوصف: | In this study, freestanding nanobiocomposite films were obtained by the sequential deposition of biopolymer-capped silver nanoparticles (AgNPs) and hyaluronic acid (HA). At first, dispersions ofAgNPs decorated with chitosan (CS) or aminocellulose (AC) were synthesized by applying high intensity ultrasound. These polycationic nanoentities were layer-by-layer assembled with the HA polyanion to generate stable 3D supramolecular constructs, where the biopolymer-capped AgNPs play the dual role of active agent and structural element. SEM images of the assemblies revealed gradual increase of thickness with the number of deposited bilayers. The composites of =50 bilayers were safe to human cells and demonstrated 100% antibacterial activity against Staphylococcus aureus and Escherichia coli. Moreover, the films containing CSAgNPs brought about the total prevention of biofilm formation reducing the cells surface adherence by up to 6 logs. Such nanobiocomposites could serve as an effective barrier to control bacterial growth on injured skin, burns, and chronic wounds. ; Peer Reviewed ; Postprint (author's final draft) |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | 9 p. |
| اللغة: | English |
| تدمد: | 1525-7797 |
| Relation: | Francesko, A., Ivanova, K., Hoyo, J., Pérez-Rafael, S., Petkova, P., Fernandes, M., Heinze, T., Mendoza, E., Tzanov, T. Bottom-up layer-by-layer assembling of antibacterial freestanding nanobiocomposite films. "Biomacromolecules", 27 Juliol 2018, vol. 19, núm. 9, p. 3628-3636.; http://hdl.handle.net/2117/121514 |
| DOI: | 10.1021/acs.biomac.8b00626 |
| الاتاحة: | http://hdl.handle.net/2117/121514 https://doi.org/10.1021/acs.biomac.8b00626 |
| Rights: | Attribution-NonCommercial-NoDerivs 3.0 Spain ; http://creativecommons.org/licenses/by-nc-nd/3.0/es/ ; Open Access |
| رقم الانضمام: | edsbas.FEDB8239 |
| قاعدة البيانات: | BASE |
| تدمد: | 15257797 |
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| DOI: | 10.1021/acs.biomac.8b00626 |