Academic Journal
Combining PSA and PET features to select candidates for salvage lymph node dissection in recurrent prostate cancer
| العنوان: | Combining PSA and PET features to select candidates for salvage lymph node dissection in recurrent prostate cancer |
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| المؤلفون: | Bravi, Carlo A., Heidenreich, Axel, Fossati, Nicola, Gandaglia, Giorgio, Suardi, Nazareno, Mazzone, Elio, Stabile, Armando, Cucchiara, Vito, Osmonov, Daniar, Juenemann, Klaus‐Peter, Karnes, R. Jeffrey, Kretschmer, Alexander, Buchner, Alexander, Stief, Christian, Hiester, Andreas, Albers, Peter, Devos, Gaëtan, Joniau, Steven, Van Poppel, Hendrik, Grubmüller, Bernhard, Shariat, Shahrokh, Tilki, Derya, Graefen, Markus, Gill, Inderbir S., Mottrie, Alexander, Karakiewicz, Pierre I., Montorsi, Francesco, Briganti, Alberto, Pfister, David |
| المصدر: | BJUI Compass ; volume 4, issue 1, page 123-129 ; ISSN 2688-4526 2688-4526 |
| بيانات النشر: | Wiley |
| سنة النشر: | 2022 |
| المجموعة: | Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: | Objective To evaluate the relationship between pre‐operative PSA value, 68 Ga‐prostate‐specific‐membrane‐antigen (PSMA) PET performance and oncologic outcomes after salvage lymph node dissection (sLND) for biochemical recurrent prostate cancer (PCa). Patients and methods The study included 164 patients diagnosed with ≤2 pelvic lymph‐node recurrence(s) of PCa documented on 68 Ga‐PSMA PET scan and treated with pelvic ± retroperitoneal sLND at 11 high‐volume centres between 2012 and 2019. Pathologic findings were correlated to PSA values at time of sLND, categorized in early (<0.5 ng/ml), low (0.5–0.99 ng/ml), moderate (1–1.5 ng/ml) and high (>1.5 ng/ml). Clinical recurrence (CR)‐free survival after sLND was calculated using multivariable analyses and plotted over pre‐operative PSA value. Results Median [interquartile range (IQR)] PSA at sLND was 1.1 (0.6, 2.0) ng/ml, and 131 (80%) patients had one positive spot at PET scan. All patients received pelvic sLND, whereas 91 (55%) men received also retroperitoneal dissection. Median (IQR) number of node removed was 15 (6, 28). The rate of positive pathology increased as a function of pre‐operative PSA value, with highest rates for patients with pre‐operative PSA > 1.5 ng/ml (pelvic‐only sLNDs: 84%; pelvic + retroperitoneal sLNDs: 90%). After sLND, PSA ≤ 0.3 ng/ml was detected in 67 (41%) men. On multivariable analyses, pre‐operative PSA was associated with PSA response ( p < 0.0001). There were 51 CRs after sLND. After adjusting for confounders, we found a significant, non‐linear relationship between PSA level at sLND and the 12‐month CR‐free survival ( p < 0.0001), with the highest probability of freedom from CR for patients who received sLND at PSA level ≥1 ng/ml. Conclusions In case of PET‐detected nodal recurrences amenable to sLND, salvage surgery was associated with the highest short‐term oncologic outcomes when performed in men with PSA ≥ 1 ng/ml. Awaiting confirmatory data from prospective trials, these findings may help physicians to ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1002/bco2.182 |
| الاتاحة: | http://dx.doi.org/10.1002/bco2.182 https://onlinelibrary.wiley.com/doi/pdf/10.1002/bco2.182 https://onlinelibrary.wiley.com/doi/full-xml/10.1002/bco2.182 |
| Rights: | http://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: | edsbas.FE74313D |
| قاعدة البيانات: | BASE |
| DOI: | 10.1002/bco2.182 |
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