Academic Journal
Basal cell carcinoma risk and solar UV exposure in occupationally relevant anatomic sites: do histological subtype, tumor localization and Fitzpatrick phototype play a role? A population-based case-control study
| العنوان: | Basal cell carcinoma risk and solar UV exposure in occupationally relevant anatomic sites: do histological subtype, tumor localization and Fitzpatrick phototype play a role? A population-based case-control study |
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| المؤلفون: | Bauer, Andrea, Haufe, E., Heinrich, L., Seidler, A., Schulze, H. J., Elsner, P., Drexler, H., Letzel, S., John, S. M., Fartasch, M., Brüning, T., Dugas-Breit, S., Gina, M., Weistenhöfer, W., Bachmann, K., Bruhn, I., Lang, B. M., Brans, R., Allam, J. P., Grobe, W., Westerhausen, S., Knuschke, P., Wittlich, M., Diepgen, T. L., Schmitt, J., Bieber, Thomas, Bonness, Sonja, Brecht, Beate, Grabbe, Stephan, Küster, Denise, Ruppert, Linda, Stephan, Victoria, Thielitz, Anja, Zimmermann, Elisabeth |
| المصدر: | http://lobid.org/resources/99370679343306441#!, 15(1):28. |
| سنة النشر: | 2020 |
| المجموعة: | Publisso (ZB MED-Publikationsportal Lebenswissenschaften) |
| مصطلحات موضوعية: | Occupation, Basal cell carcinoma, Outdoor work, Research, Solar UV exposure, Localization, Histological subtype, Fitzpatrick phototype |
| الوصف: | Background!#!A two-fold risk increase to develop basal cell carcinoma was seen in outdoor workers exposed to high solar UV radiation compared to controls. However, there is an ongoing discussion whether histopathological subtype, tumor localization and Fitzpatrick phototype may influence the risk estimates.!##!Objectives!#!To evaluate the influence of histological subtype, tumor localization and Fitzpatrick phototype on the risk to develop basal cell carcinoma in highly UV-exposed cases and controls compared to those with moderate or low solar UV exposure.!##!Methods!#!Six hundred forty-three participants suffering from incident basal cell carcinoma in commonly sun-exposed anatomic sites (capillitium, face, lip, neck, dorsum of the hands, forearms outside, décolleté) of a population-based, case-control, multicenter study performed from 2013 to 2015 in Germany were matched to controls without skin cancer. Multivariate logistic regression analysis was conducted stratified for histological subtype, phototype 1/2 and 3/4. Dose-response curves adjusted for age, age!##!Results!#!Participants with high versus no (OR 2.08; 95% CI 1.24-3.50; !##!Conclusion!#!The risk to develop basal cell carcinoma in highly occupationally UV-exposed skin was doubled consistently, independent of histological subtype, tumor localization and Fitzpatrick phototype. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | https://repository.publisso.de/resource/frl:6452490; https://doi.org/10.1186/s12995-020-00279-8; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7488106/ |
| DOI: | 10.1186/s12995-020-00279-8 |
| الاتاحة: | https://repository.publisso.de/resource/frl:6452490 https://doi.org/10.1186/s12995-020-00279-8 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7488106/ |
| Rights: | https://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: | edsbas.FE3B18F |
| قاعدة البيانات: | BASE |
| DOI: | 10.1186/s12995-020-00279-8 |
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