Academic Journal
Carnosol alleviates sevoflurane‑induced cognitive dysfunction by mediating NF‑κB pathway in aged rats
| العنوان: | Carnosol alleviates sevoflurane‑induced cognitive dysfunction by mediating NF‑κB pathway in aged rats |
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| المؤلفون: | Li, Qing, Zhang, Xianjie, Li, Siyuan, Li, Wen, Teng, Yunpeng, Zhou, Yukai, Xiong, Hongfei |
| المصدر: | Drug Development Research ; volume 83, issue 6, page 1342-1350 ; ISSN 0272-4391 1098-2299 |
| بيانات النشر: | Wiley |
| سنة النشر: | 2022 |
| المجموعة: | Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: | Postoperative Cognitive Dysfunction (POCD) is a neurological disorder of unconsciousness due to cognitive regression after surgical anesthesia. However, the specific mechanism has not yet been clarified. Sevoflurane (SEV) is one of the most commonly used anesthetics in clinical practice, and how SEV mediates the generation of POCD is unclear. Carnosol, a natural ingredient, has been reported to have various beneficial effects such as anti‐inflammatory, immune enhancement, and so forth, but how it ameliorates SEV‐mediated neurotoxicity remains unclear. This study aimed to induce a POCD model in aged rats by SEV and to elucidate how Carnosol ameliorated SEV‐mediated neurotoxicity. The effects of Carnosol on the expression of inflammatory factors in rat hippocampus mediated by SEV were determined by enzyme‐linked immunoassay and polymerase chain reaction experiments; the effects of Carnosol on the expressions of Iba‐1 and glial fibrillary acidic protein after SEV‐mediated activation of rat microglia were clarified by immunofluorescence and Western blotting (WB); The effects of Carnosol on SEV‐mediated neuronal apoptosis were studied by terminal deoxynucleotidyl transferase dUTP nick end labeling and WB; the specific signaling pathways regulated by Carnosol were elucidated by WB. The results showed that Carnosol can improve the cognitive dysfunction and reduce neuroinflammation in aged rats induced by SEV; Carnosol can reduce the activation of microglia and inhibit neuronal apoptosis in aged rats induced by SEV; Carnosol can phosphorylate p65 and nuclear factor of kappa light polypeptide gene enhancer in B‐cells inhibitor, alpha regulates the nuclear factor kappa‐light‐chain‐enhancer of activated B cells (NF‐κB) pathway. Carnosol can attenuate SEV‐induced neuroinflammation, prevent microglial activation and inhibit neuronal apoptosis by modulating the NF‐κB pathway. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1002/ddr.21963 |
| الاتاحة: | https://doi.org/10.1002/ddr.21963 https://onlinelibrary.wiley.com/doi/pdf/10.1002/ddr.21963 https://onlinelibrary.wiley.com/doi/full-xml/10.1002/ddr.21963 |
| Rights: | http://onlinelibrary.wiley.com/termsAndConditions#vor |
| رقم الانضمام: | edsbas.FE382C76 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1002/ddr.21963 |
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