Academic Journal
Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk
| العنوان: | Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk |
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| المؤلفون: | Warren HR, Evangelou E, Cabrera CP, Gao H, Ren MX, Mifsud B, Ntalla I, Surendran P, Liu CY, Cook JP, Kraja AT, Drenos F, Loh M, Verweij N, Marten J, Karaman I, Lepe MPS, O'Reilly PF, Knight J, Snieder H, Kato N, He J, Tai ES, Said MA, Porteous D, Alver M, Poulter N, Farrall M, Gansevoort RT, Padmanabhan S, Magi R, Stanton A, Connell J, Bakker SJL, Metspalu A, Shields DC, Thom S, Brown M, Sever P, Esko T, Hayward C, van der Harst P, Saleheen D, Chowdhury R, Chambers JC, Chasman DI, Chakravarti A, Newton-Cheh C, Lindgren CM, Levy D, Kooner JS, Keavney B, Tomaszewski M, Samani NJ, Howson JMM, Tobin MD, Munroe PB, Ehret GB, Wain LV, Barnes MR, Tzoulaki J, Caulfield MJ, Elliott P, Vaez A, Jansen R, Joehanes R, van der Most PJ, Erzurumluoglu AM, O'Reilly P, Rose LM, Verwoert GC, Hottenga JJ, Strawbridge RJ, Arking DE, Hwang SJ, Guo XQ, Kutalik Z, Trompet S, Shrine N, Teumer A, Ried JS, Bis JC, Smith AV, Amin N, Nolte IM, Lyytikainen LP, Mahajan A, Wareham NJ, Hofer E, Joshi PK, Kristiansson K, Traglia M, Havulinna AS, Goel A, Nalls MA, Sober S, Vuckovic D, Luan JA, Del Greco F, Ayers KL, Marrugat J, Ruggiero D, Lopez LM, Niiranen T, Enroth S, Jackson AU, Nelson CP, Huffman JE, Zhang WH, Gandin I, Harris SE, Zemonik T, Lu YC, Shah N, de Borst MH, Mangino M, Prins BP, Campbell A, Li-Gao RF, Chauhan G, Oldmeadow C, Abecasis G, Abedi M, Barbieri CM, Batini C, Blake T, Boehnke M, Bottinger EP, Braund PS, Brumat M, Campbell H, Cocca M, Collins F, Cordell HJ, Damman JJ, Davies G, de Geus EJ, de Mutsert R, Deelen J, Demirkale Y, Doney ASF, Dorr M, Ferreira T, Franberg M, Giedraitis V, Gieger C, Giulianini F, Gow AJ, Hamsten A, Harris TB, Hofman A, Holliday EG, Jarvelin MR, Johansson A, Johnson AD, Jousilahti P, Jula A, Kahonen M, Kathiresan S, Khaw KT, Kolcic I, Koskinen S, Langenberg C, Larson M, Launer LJ, Lehne B, Liewald DCM, Lin L, Lind L, Mach F, Mamasoula C, Menni C, Milaneschi Y, Morgan A, Morris AD, Morrison AC, Munson PJ, Nandakumar P, Nguyen QT, Nutile T, Oldehinkel AJ, Oostra BA, Org E, Palotie A, Pare G, Pattie A, Penninx BWJH, Pramstaller PP, Raitakari OT, Rice K, Ridker PM, Riese H, Ripatti S, Robino A, Rotter JI, Rudan I, Saba Y, Saint Pierre A, Sala CF, Sarin AP, Schmidt R, Scott R, Seelen MA, Siscovick D, Sorice R, Stott DJ, Sundstrom J, Swertz M, Taylor KD, Tzoulaki I, Tzourio C, Uitterlinden AG, Volker U, Vollenweider P, Wild S, Willemsen G, Wright AF, Yao J, Theriault S, Conen D, John A, Debette S, Mook-Kanamori DO, Zeggini E, Spector TD, Palmer CNA, Vergnaud AC, Loos RJF, Polasek O, Starr JM, Girotto G, Vitart V, Tuomilehto J, Gyllensten U, Knekt P, Deary IJ, Ciullo M, Elosua R, Keavney BD, Hicks AA, Scott RA, Gasparini P, Laan M, Liu YM, Watkins H, Hartman CA, Salomaa V, Toniolo D, Perola M, Wilson JF, Schmidt H, Zhao JH, Lehtimaki T, van Duijn CM, Gudnason V, Psaty BM, Peters A, Rettig R, James A, Jukema JW, Strachan DP, Palmas W, Ingelsson E, Boomsma DI, Franco OH, Bochud M, Morris AP |
| المساهمون: | H. Warren, E. Evangelou, C. Cabrera, H. Gao, M. Ren, B. Mifsud, I. Ntalla, P. Surendran, C. Liu, J. Cook, A. Kraja, F. Dreno, M. Loh, N. Verweij, J. Marten, I. Karaman, M. Lepe, P. O'Reilly, J. Knight, H. Snieder, N. Kato, J. He, E. Tai, M. Said, D. Porteou, M. Alver, N. Poulter, M. Farrall, R. Gansevoort, S. Padmanabhan, R. Magi, A. Stanton, J. Connell, S. Bakker, A. Metspalu, D. Shield, S. Thom, M. Brown, P. Sever, T. Esko, C. Hayward, P. van der Harst, D. Saleheen, R. Chowdhury, J. Chamber, D. Chasman, A. Chakravarti, C. Newton-Cheh, C. Lindgren, D. Levy, J. Kooner, B. Keavney, M. Tomaszewski, N. Samani, J. Howson, M. Tobin, P. Munroe, G. Ehret, L. Wain, M. Barne, J. Tzoulaki, M. Caulfield, P. Elliott, A. Vaez, R. Jansen, R. Joehane, P. van der Most, A. Erzurumluoglu, L. Rose, G. Verwoert, J. Hottenga, R. Strawbridge, D. Arking, S. Hwang, X. Guo, Z. Kutalik, S. Trompet, N. Shrine, A. Teumer, J. Ried, J. Bi, A. Smith, N. Amin, I. Nolte, L. Lyytikainen, A. Mahajan, N. Wareham, E. Hofer, P. Joshi, K. Kristiansson, M. Traglia, A. Havulinna, A. Goel, M. Nall, S. Sober |
| سنة النشر: | 2017 |
| المجموعة: | The University of Milan: Archivio Istituzionale della Ricerca (AIR) |
| مصطلحات موضوعية: | Settore MEDS-24/A - Statistica medica |
| الوصف: | Elevated blood pressure is the leading heritable risk factor for cardiovascular disease worldwide. We report genetic association of blood pressure (systolic, diastolic, pulse pressure) among UK Biobank participants of European ancestry with independent replication in other cohorts, and robust validation of 107 independent loci. We also identify new independent variants at 11 previously reported blood pressure loci. In combination with results from a range of in silico functional analyses and wet bench experiments, our findings highlight new biological pathways for blood pressure regulation enriched for genes expressed in vascular tissues and identify potential therapeutic targets for hypertension. Results from genetic risk score models raise the possibility of a precision medicine approach through early lifestyle intervention to offset the impact of blood pressure-raising genetic variants on future cardiovascular disease risk. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/28135244; info:eu-repo/semantics/altIdentifier/wos/WOS:000394917800014; volume:49; issue:3; firstpage:403; lastpage:415; numberofpages:13; journal:NATURE GENETICS; https://hdl.handle.net/2434/1101513 |
| DOI: | 10.1038/ng.3768 |
| الاتاحة: | https://hdl.handle.net/2434/1101513 https://doi.org/10.1038/ng.3768 |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.FE334DF7 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1038/ng.3768 |
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