Academic Journal
Mortality at one year after transcatheter aortic valve replacement – Relation of age and comorbidities
| العنوان: | Mortality at one year after transcatheter aortic valve replacement – Relation of age and comorbidities |
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| المؤلفون: | Strange, Jarl E., Fosbøl, Emil L., Sindet-Pedersen, Caroline, Havers-Borgersen, Eva, Køber, Lars, Gislason, Gunnar H., Olesen, Jonas B. |
| المصدر: | Strange , J E , Fosbøl , E L , Sindet-Pedersen , C , Havers-Borgersen , E , Køber , L , Gislason , G H & Olesen , J B 2022 , ' Mortality at one year after transcatheter aortic valve replacement – Relation of age and comorbidities ' , IJC Heart and Vasculature , vol. 43 , 101157 . https://doi.org/10.1016/j.ijcha.2022.101157 |
| سنة النشر: | 2022 |
| المجموعة: | University of Copenhagen: Research / Forskning ved Københavns Universitet |
| مصطلحات موضوعية: | Age, Comorbidities, Mortality, Prognosis, Transcatheter aortic valve replacement |
| الوصف: | Background: Of patients undergoing transcatheter aortic valve replacement (TAVR), 80–90 % are at extreme, high, or intermediate risk. Patient selection considering futile outcomes in these groups is difficult as significant comorbidity burden is common. Thus, we examined 1-year mortality after TAVR according to age and comorbidities. Methods: Between 2008 and 2021 all Danish TAVR-patients were included. From a multivariate Cox-regression model, significant characteristics associated with 1-year all-cause mortality were identified. The study population was divided into four groups according to number of significant comorbidities present at baseline: Low (0 comorbidities), mild (1 comorbidity), moderate (2 comorbidities), and high (3 or more comorbidities). The 1-year risk of all-cause mortality with 95 % confidence intervals (CI) was estimated by each group. Results: In total, 7,104 patients underwent TAVR. Significant covariates associated with 1-year all-cause mortality were chronic kidney disease, heart failure, chronic obstructive pulmonary disease, peripheral artery disease, and age ≥ 85 years. The four baseline groups comprised low (n = 2,666), mild (n = 2,814), moderate (n = 1,246), and high comorbidity burden (n = 378). The 1-year risk of all-cause mortality was 5.5 % (95 %CI: 4.6–6.4 %) in the low baseline comorbidity burden group. Conversely, the 1-year risk of all-cause mortality was 25.0 % (95 %CI: 20.4–29.3 %) in the high baseline burden group. Conclusions: In a national sample of TAVR patients, readily available information on age and comorbidities, can be used to identify a high-risk group with 25 % 1-year mortality. This provides physicians and patients with an easy-to-understand view on 1-year prognosis after TAVR and may complement patient selection for improved long-term outcomes. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| DOI: | 10.1016/j.ijcha.2022.101157 |
| الاتاحة: | https://researchprofiles.ku.dk/da/publications/mortality-at-one-year-after-transcatheter-aortic-valve-replacement--relation-of-age-and-comorbidities(4af1222c-fdb4-4c33-928e-ba4e6d0d1521).html https://doi.org/10.1016/j.ijcha.2022.101157 https://curis.ku.dk/ws/files/341059694/1_s2.0_S2352906722002068.pdf |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.FDDFC125 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.ijcha.2022.101157 |
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