Academic Journal
Subcutaneous cladribine to treat multiple sclerosis: Experience in 208 patients
| العنوان: | Subcutaneous cladribine to treat multiple sclerosis: Experience in 208 patients |
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| المؤلفون: | Allen-Philbey, K., De Trane, S., Mao, Z., Álvarez-González, C., Mathews, J., MacDougall, A., Stennett, A., Zhou, X., Yildiz, O., Adams, A., Bianchi, L., Blain, C., Chapman, C., Chung, K., Constantinescu, C. S., Dalton, C., Farrell, R. A., Fisniku, L., Ford, H., Gran, B., Hobart, J., Khaleeli, Z., Mattoscio, M., Pavitt, S., Pearson, O., Peruzzotti-Jametti, L., Scalfari, A., Sharrack, B., Silber, E., Tallantyre, E., Webb, S., Turner, B. P., Marta, M., Gnanapavan, S., Juliusson, G., Giovannoni, G., Baker, D., Schmierer, K. |
| بيانات النشر: | SAGE Publications |
| سنة النشر: | 2021 |
| المجموعة: | Cardiff University: ORCA (Online Research @ Cardiff) |
| الوصف: | Objective: To report on safety and effectiveness of subcutaneous cladribine (Litak®) in multiple sclerosis (MS) patients. Methods: Litak® was offered to MS-patients irrespective of disease course. Litak® 10 mg was administered for 3–4 days during week 1. Based on lymphocyte count at week 4, patients received another 0–3 doses at week 5. A second course was administered 11 months later. Follow-up included adverse events, relapses, expanded disability status scale (EDSS), 9-hole-peg and Timed-25-foot-walking tests, no-evidence-of-disease-activity (NEDA), no-evidence-of-progression-or-active-disease (NEPAD), MRI, cerebrospinal fluid (CSF) neurofilament light chain (NfL), and lymphocyte counts. Results: In all, 208 patients received at least one course of treatment. Age at baseline was 44 (17–72) years and EDSS 0–8.5. Cladribine was generally well tolerated. One myocardial infarction, one breast cancer, and three severe skin reactions occurred without long-term sequelae. Two patients died (one pneumonia, one encephalitis). Lymphopenia grade 3 occurred in 5% and grade 4 in 0.5%. In 94 out of 116 pwMS with baseline and follow-up (BaFU) data after two treatment courses, EDSS remained stable or improved. At 18 months, 64% of patients with relapsing MS and BaFU data (n = 39) had NEDA. At 19 months, 62% of patients with progressive MS and BaFU data (n = 13) had NEPAD. Of n = 13 patients whose CSF-NfL at baseline was elevated, 77% were normalised within 12 months. Conclusions: Litak® was well tolerated. Effectiveness in relapsing MS appeared similar to cladribine tablets and was encouraging in progressive MS. Our data suggest cladribine may be safe and effective in MS-patients irrespective of their disease stage. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| Relation: | https://orca.cardiff.ac.uk/id/eprint/144928/3/17562864211057661.pdf; Allen-Philbey, K., De Trane, S., Mao, Z., Álvarez-González, C., Mathews, J., MacDougall, A., Stennett, A., Zhou, X., Yildiz, O., Adams, A., Bianchi, L., Blain, C., Chapman, C., Chung, K., Constantinescu, C. S., Dalton, C., Farrell, R. A., Fisniku, L., Ford, H., Gran, B., Hobart, J., Khaleeli, Z., Mattoscio, M., Pavitt, S., Pearson, O., Peruzzotti-Jametti, L., Scalfari, A., Sharrack, B., Silber, E., Tallantyre, E. https://orca.cardiff.ac.uk/view/cardiffauthors/A466853R.html orcid:0000-0002-3760-6634 orcid:0000-0002-3760-6634, Webb, S., Turner, B. P., Marta, M., Gnanapavan, S., Juliusson, G., Giovannoni, G., Baker, D. and Schmierer, K. 2021. Subcutaneous cladribine to treat multiple sclerosis: Experience in 208 patients. Therapeutic Advances in Neurological Disorders 14 , pp. 1-16. 10.1177/17562864211057661 https://doi.org/10.1177/17562864211057661 file https://orca.cardiff.ac.uk/id/eprint/144928/3/17562864211057661.pdf |
| DOI: | 10.1177/17562864211057661 |
| الاتاحة: | https://orca.cardiff.ac.uk/id/eprint/144928/ https://doi.org/10.1177/17562864211057661 https://orca.cardiff.ac.uk/id/eprint/144928/3/17562864211057661.pdf |
| Rights: | cc_by_nc |
| رقم الانضمام: | edsbas.FDB22E82 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1177/17562864211057661 |
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