Academic Journal
Adult onset asthma and interaction between genes and active tobacco smoking: The GABRIEL consortium
| العنوان: | Adult onset asthma and interaction between genes and active tobacco smoking: The GABRIEL consortium |
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| المؤلفون: | Vonk, J, M, Scholtens, S., Postma, D, S, Moffatt, M, F, Jarvis, D., Ramasamy, A., Wjst, M., Omenaas, E, R, Bouzigon, E., Demenais, F., Nadif, R., Siroux, V., Polonikov, A, V, Solodilova, M., Ivanov, V, P, Curjuric, I., Imboden, M., Kumar, A., Probst-Hensch, N., Ogorodova, L, M, Puzyrev, V, P, Bragina, E. Yu, Freidin, M, B, Nolte, I, M, Farrall, A, M, Cookson, W, O C M, Strachan, D, P, Koppelman, G, H, Boezen, H, M |
| المساهمون: | University of Groningen, University Medical Center Groningen, Department of Epidemiology, Groningen, Groningen Research Institute for Asthma and COPD, Department of Pulmonary Diseases & Tuberculosis Groningen, University of Groningen Groningen -University Medical Center Groningen Groningen (UMCG), Imperial College, Hammersmith Hospital, Imperial College, UK, MRC-PHE Centre for Environment and Health, Imperial College, London, Population Health and Occupational Disease, Imperial College, London, Institute of Medical Statistics and Epidemiology (IMSE), Klinikum Rechts der Isar, Technical University, Munich, Comprehensive Pneumology Center Munich Munich, Germany ( CPC -M), German Center for Lung Research - DZL Munich, Germany, Centre for Clinical Research, Haukeland University Hospital, Bergen, Univ Paris Diderot, Sorbonne Paris Cité, Institut Universitaire d'Hématologie, Paris, Variabilité Génétique et Maladies Humaines (U946), Institut Universitaire d'Hématologie (IUH), Université Paris Diderot - Paris 7 (UPD7)-Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM), Vieillissement et Maladies chroniques : approches épidémiologique et de santé publique (VIMA), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut National de la Santé et de la Recherche Médicale (INSERM), Univ. Grenoble Alpes, IAB, Team of Environmental Epidemiology applied to Reproduction and Respiratory Health, Grenoble, Kursk State Medical University, Department of Biology, Medical Genetics and Ecology, Kursk, Department of Epidemiology and Public Health, Swiss Tropical and Public Health Institute, Basel, University Hospital Basel Basel, Wellcome Trust Centre for Human Genetics, Siberian State Medical University, Tomsk, Russia, Research Institute of Medical Genetics, Tomsk NRMC, Division of Respiratory Sciences, Imperial College, London, Population Health Research Institute, St George's, University of London, London, Department of Pediatrics Groningen, Universitair Medisch Centrum Groningen, The GABRIEL study (a multidisciplinary study to identify the genetic and environmental causes of asthma in the European Community) was supported by the European Commission, contract number 018996 under the Integrated Program LSH-2004-1.2.5-1. The separate cohort were also supported by local funding organizations (see supplementary material). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. |
| المصدر: | ISSN: 1932-6203. |
| بيانات النشر: | HAL CCSD Public Library of Science |
| سنة النشر: | 2017 |
| المجموعة: | Université de Versailles Saint-Quentin-en-Yvelines: HAL-UVSQ |
| مصطلحات موضوعية: | [SDV.MHEP.PSR]Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract, [SDV.EE.SANT]Life Sciences [q-bio]/Ecology, environment/Health, [SDV.GEN]Life Sciences [q-bio]/Genetics |
| الوصف: | International audience ; Background Genome-wide association studies have identified novel genetic associations for asthma, but without taking into account the role of active tobacco smoking. This study aimed to identify novel genes that interact with ever active tobacco smoking in adult onset asthma. Methods We performed a genome-wide interaction analysis in six studies participating in the GABRIEL consortium following two meta-analyses approaches based on 1) the overall interaction effect and 2) the genetic effect in subjects with and without smoking exposure. We performed a discovery meta-analysis including 4,057 subjects of European descent and replicated our findings in an independent cohort (LifeLines Cohort Study), including 12,475 subjects.Results: First approach: 50 SNPs were selected based on an overall interaction effect at p<10-4. The most pronounced interaction effect was observed for rs9969775 on chromosome 9 (discovery meta-analysis: ORint = 0.50, p = 7.63*10-5, replication: ORint = 0.65, p = 0.02). Second approach: 35 SNPs were selected based on the overall genetic effect in exposed subjects (p <10-4). The most pronounced genetic effect was observed for rs5011804 on chromosome 12 (discovery meta-analysis ORint = 1.50, p = 1.21*10-4; replication: ORint = 1.40, p = 0.03).Conclusions: Using two genome-wide interaction approaches, we identified novel polymorphisms in non-annotated intergenic regions on chromosomes 9 and 12, that showed suggestive evidence for interaction with active tobacco smoking in the onset of adult asthma. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | hal-04306121; https://hal.science/hal-04306121; https://hal.science/hal-04306121/document; https://hal.science/hal-04306121/file/pone.0172716.pdf |
| DOI: | 10.1371/journal.pone.0172716 |
| الاتاحة: | https://hal.science/hal-04306121 https://hal.science/hal-04306121/document https://hal.science/hal-04306121/file/pone.0172716.pdf https://doi.org/10.1371/journal.pone.0172716 |
| Rights: | info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.FDA50F5A |
| قاعدة البيانات: | BASE |
| DOI: | 10.1371/journal.pone.0172716 |
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