Academic Journal
Doublecortin expression in CD8+ T-cells and microglia at sites of amyloid-β plaques: A potential role in shaping plaque pathology?
| العنوان: | Doublecortin expression in CD8+ T-cells and microglia at sites of amyloid-β plaques: A potential role in shaping plaque pathology? |
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| المؤلفون: | Unger, Michael S, Marschallinger, Julia, Kaindl, Julia, Klein, Barbara, Johnson, Mary, Khundakar, Ahmad A, Roßner, Steffen, HENEKA, Michael, Couillard-Despres, Sebastien, Rockenstein, Edward, Masliah, Eliezer, Attems, Johannes, Aigner, Ludwig |
| المصدر: | Alzheimer's and Dementia: the Journal of the Alzheimer's Association, 14 (8), 1022 - 1037 (2018-08) |
| بيانات النشر: | Elsevier Inc. |
| سنة النشر: | 2018 |
| المجموعة: | University of Luxembourg: ORBilu - Open Repository and Bibliography |
| مصطلحات موضوعية: | Alzheimer's disease, Doublecortin (DCX), Microglia, T-cells, DCX protein, human, mouse, Doublecortin Domain Proteins, Doublecortin Protein, Membrane Glycoproteins, Microtubule-Associated Proteins, Neuropeptides, Receptors, Immunologic, Trem2 protein, Alzheimer Disease/genetics, Alzheimer Disease/pathology, Animals, Brain/pathology, Disease Models, Animal, Female, Humans, Membrane Glycoproteins/genetics, Mice, Transgenic, Microglia/pathology, Microglia/ultrastructure, Microscopy, Electron |
| الوصف: | peer reviewed ; INTRODUCTION: One characteristic of Alzheimer's disease is the formation of amyloid-β plaques, which are typically linked to neuroinflammation and surrounded by inflammatory cells such as microglia and infiltrating immune cells. METHODS: Here, we describe nonneurogenic doublecortin (DCX) positive cells, DCX being generally used as a marker for young immature neurons, at sites of amyloid-β plaques in various transgenic amyloid mouse models and in human brains with plaque pathology. RESULTS: The plaque-associated DCX+ cells were not of neurogenic identity, instead most of them showed coexpression with markers for microglia (ionized calcium-binding adapter molecule 1) and for phagocytosis (CD68 and TREM2). Another subpopulation of plaque-associated DCX+ cells was negative for ionized calcium-binding adapter molecule 1 but was highly positive for the pan-leukocyte marker CD45. These hematopoietic cells were identified as CD3-and CD8-positive and CD4-negative T-cells. DISCUSSION: Peculiarly, the DCX+/ionized calcium-binding adapter molecule 1+ microglia and DCX+/CD8+ T-cells were closely attached, suggesting that these two cell types are tightly interacting and that this interaction might shape plaque pathology. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1552-5260 1552-5279 |
| Relation: | https://api.elsevier.com/content/article/PII:S1552526018300712?httpAccept=text/xml; urn:issn:1552-5260; urn:issn:1552-5279; https://orbilu.uni.lu/handle/10993/60934; info:hdl:10993/60934; info:pmid:29630865; wos:000441572700006 |
| DOI: | 10.1016/j.jalz.2018.02.017 |
| الاتاحة: | https://orbilu.uni.lu/handle/10993/60934 https://orbilu.uni.lu/bitstream/10993/60934/1/Doublecortin%20expression%20in%20CD8%2b%20T-cells%20and%20microglia%20at%20sites%20of%20amyloid-%ce%b2%20plaques%20A%20potential%20role%20in%20shaping%20plaque%20pathology.pdf https://doi.org/10.1016/j.jalz.2018.02.017 |
| Rights: | open access ; http://purl.org/coar/access_right/c_abf2 ; info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.FD923FA0 |
| قاعدة البيانات: | BASE |
| تدمد: | 15525260 15525279 |
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| DOI: | 10.1016/j.jalz.2018.02.017 |