التفاصيل البيبلوغرافية
| العنوان: |
Dietary nitrate does not reduce oxygen cost of exercise or improve muscle mitochondrial function in patients with mitochondrial myopathy |
| المؤلفون: |
Nabben, MW, Schmitz, JPJ Joep, Ciapaite, J Jolita, Clercq, Carlijn MP le, Riel, NAW Natal van, Haak, Harm R, Nicolaij, K Klaas, Coo, IFM de, Smeets, Hubert, Praet, Stephan FE, Loon, LJC Luc van, Prompers, JJ Jeanine |
| المصدر: |
ISSN:0363-6119. |
| بيانات النشر: |
American Physiological Society |
| سنة النشر: |
2017 |
| المجموعة: |
Eindhoven University of Technology (TU/e): Research Portal |
| الوصف: |
Muscle weakness and exercise intol erance negatively affect the quality of life of patients with mitochondrial myopathy. Short-term dietary nitrate supplementation has been shown to improve exercise performance and reduce oxygen cost of exercise in healthy humans and trained athletes. We investigated whether 1 wk of dietary inorganic nitrate supplementation decreases the oxygen cost of exercise and improves mitochondrial function in patients with mitochondrial myopathy. Ten patients with mitochondrial myopathy (40 ± 5 yr, maximal whole body oxygen uptake = 21.2 ± 3.2 ml·min -1 ·kg body wt -1 , maximal work load = 122 ± 26 W) received 8.5 mg·kg body wt -1 ·day -1 inorganic nitrate (~7 mmol) for 8 days. Whole body oxygen consumption at 50% of the maximal work load, in vivo skeletal muscle oxidative capacity (evaluated from postexercise phosphocreatine recovery using 31 P-magnetic resonance spectroscopy), and ex vivo mitochondrial oxidative capacity in permeabilized skinned muscle fibers (measured with high-resolution respirometry) were determined before and after nitrate supplementation. Despite a sixfold increase in plasma nitrate levels, nitrate supplementation did not affect whole body oxygen cost during submaximal exercise. Additionally, no beneficial effects of nitrate were found on in vivo or ex vivo muscle mitochondrial oxidative capacity. This is the first time that the therapeutic potential of dietary nitrate for patients with mitochondrial myopathy was evaluated. We conclude that 1 wk of dietary nitrate supplementation does not reduce oxygen cost of exercise or improve mitochondrial function in the group of patients tested. |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| Relation: |
http://repository.tue.nl/875247 |
| الاتاحة: |
http://repository.tue.nl/875247 |
| Rights: |
Copyright (c) Nabben, MW ; Copyright (c) Schmitz, JPJ Joep ; Copyright (c) Ciapaite, J Jolita ; Copyright (c) Clercq, Carlijn MP le ; Copyright (c) Riel, NAW Natal van ; Copyright (c) Haak, Harm R ; Copyright (c) Nicolaij, K Klaas ; Copyright (c) Coo, IFM de ; Copyright (c) Smeets, Hubert ; Copyright (c) Praet, Stephan FE ; Copyright (c) Loon, LJC Luc van ; Copyright (c) Prompers, JJ Jeanine |
| رقم الانضمام: |
edsbas.FD8D067A |
| قاعدة البيانات: |
BASE |