Academic Journal
The NIQ of Lopinavir is Predictive of a 48-Week Virological Response in Highly Treatment-Experienced HIV-1-Infected Subjects Treated with a Lopinavir/Ritonavir-Containing Regimen
| العنوان: | The NIQ of Lopinavir is Predictive of a 48-Week Virological Response in Highly Treatment-Experienced HIV-1-Infected Subjects Treated with a Lopinavir/Ritonavir-Containing Regimen |
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| المؤلفون: | Castagna, Antonella, Gianotti, Nicola, Galli, Laura, Danise, Anna, Hasson, Hamid, Boeri, Enzo, Hoetelmans, Richard, Nauwelaers, David, Lazzarin, Adriano |
| المصدر: | Antiviral Therapy ; volume 9, issue 4, page 537-543 ; ISSN 1359-6535 2040-2058 |
| بيانات النشر: | SAGE Publications |
| سنة النشر: | 2004 |
| الوصف: | Objective To investigate the normalized inhibitory quotient (NIQ) of lopinavir (LPV) as a predictor of 48-week virological responses to a lopinavir/ritonavir (LPV/RTV)-containing regimen in highly treatment-experienced patients. Design We calculated the NIQ for 59 patients who completed 48 weeks’ treatment and assessed the factors predicting a week-48 virological response. Methods The NIQ was calculated by dividing each subject's IQ (LPV C trough /fold change in LPV susceptibility, as assessed by VirtualPhenotype™) by a reference IQ (mean population LPV C trough /fold change in LPV IC 50 , as assessed by VirtualPhenotype™). HIV-1 RNA was assessed by NASBA (quantification limit: 80 copies/ml). The general linear model and multiple logistic regression, respectively, were used to estimate the independent predictors of a change in viral load and HIV-1 RNA <80 copies/ml. Results The median (interquartile range) baseline levels of CD4+ cells and HIV-1 RNA were 251 (141–385) cells/μl and 4.85 (4.49–5.23) log 10 copies/ml, respectively. The median NIQ was 2.2 (0.5–14). At week 48, the median decrease in HIV-1 RNA was 1.4 (0.59–2.79) log 10 copies/ml ( P<0.0001), with 24 subjects (41%) reaching <80 copies/ml. Baseline HIV-1 RNA ( P=0.001), CD4+ cells ( P=0.002) and NIQ ( P=0.0006) independently predicted the week-48 change in viral load, whereas baseline CD4+ cells ( P=0.011) and NIQ ( P=0.009) independently predicted a week-48 HIV-1 RNA level of <80 copies/ml. Conclusion The LPV NIQ independently predicts virological responses to an LPV/RTV-containing regimen in highly treatment-experienced HIV-1-infected patients. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1177/135965350400900408 |
| الاتاحة: | https://doi.org/10.1177/135965350400900408 https://journals.sagepub.com/doi/pdf/10.1177/135965350400900408 |
| Rights: | https://journals.sagepub.com/page/policies/text-and-data-mining-license |
| رقم الانضمام: | edsbas.FD85E5E7 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1177/135965350400900408 |
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